fetuin-A Antibody (H-8): sc-166531
- fetuin-A Antibody (H-8) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- raised against amino acids 68-367 of fetuin-A of human origin
- Anti-fetuin-A Antibody (H-8) is recommended for detection of fetuin-A of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-fetuin-A Antibody (H-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for fetuin-A Antibody (H-8) for WB applications. These reagents are now offered in bundles with fetuin-A Antibody (H-8) (see ordering information below).
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fetuin-A Antibody (H-8) is a mouse monoclonal IgG2b kappa light chain antibody that detects fetuin-A in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-fetuin-A antibody (H-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Fetuin-A, also known as α-2-HS-glycoprotein, is a secreted plasma protein primarily produced in hepatocytes, monocytes/macrophages, and bone tissue, and expression is notably down-regulated during injury and inflammation. Fetuin-A plays a crucial role in calcium and barium ion transport in the bloodstream, contributing to serum calcium homeostasis and mineralization, which are vital for maintaining bone health and preventing disorders related to mineral imbalance. Fetuin-A acts as an acute phase anti-inflammatory mediator, essential for modulating the innate immune response following tissue injury. During inflammatory processes, circulating fetuin-A levels significantly decrease as fetuin-A associates with macrophage membranes, enhancing the uptake of cationic small molecules and facilitating mechanisms that deactivate macrophages. The biologically active form of fetuin-A is generated from a precursor protein that undergoes cleavage at the amino terminus, resulting in two chains linked by a single disulfide bond, underscoring the importance of structural integrity for functional activity.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
fetuin-A Antibody (H-8) References:
- Fetuin-A and the cardiovascular system. | Mori, K., et al. 2012. Adv Clin Chem. 56: 175-95. PMID: 22397032
- The role of fetuin-A in mineral trafficking and deposition. | Cai, MM., et al. 2015. Bonekey Rep. 4: 672. PMID: 25987986
- From infancy to aging: Biological and behavioral modifiers of Fetuin-A. | Robinson, KN. and Teran-Garcia, M. 2016. Biochimie. 124: 141-149. PMID: 26740309
- Identification of fucosylated Fetuin-A as a potential biomarker for cholangiocarcinoma. | Betesh, L., et al. 2017. Proteomics Clin Appl. 11: PMID: 28561948
- Effects of nutritional status on serum fetuin-A level. | Icer, MA. and Yıldıran, H. 2020. Crit Rev Food Sci Nutr. 60: 1938-1946. PMID: 31232084
- Fetuin-A and risk of diabetes-related vascular complications: a prospective study. | Birukov, A., et al. 2022. Cardiovasc Diabetol. 21: 6. PMID: 34998417
- Fetuin-A in Activated Liver Macrophages Is a Key Feature of Non-Alcoholic Steatohepatitis. | Etienne, Q., et al. 2022. Metabolites. 12: PMID: 35888749
- Effect of Fetuin-A and oxidative stress on the occurrence of unexplained infertility. | Taşkan, T., et al. 2023. Turk J Obstet Gynecol. 20: 113-119. PMID: 37260171
- Fetuin-A levels in association with calcific aortic valve disease: A meta-analysis. | Larik, MO. 2023. Atheroscler Plus. 54: 27-29. PMID: 37822974
- Fetal hepatocytes protect the HSPC genome via fetuin-A. | Guo, XL., et al. 2025. Nature. 637: 402-411. PMID: 39633051
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
fetuin-A Antibody (H-8) | sc-166531 | 200 µg/ml | $322.00 | |||
fetuin-A Antibody (H-8): m-IgGκ BP-HRP Bundle | sc-521644 | 200 µg Ab, 40 µg BP | $361.00 | |||
fetuin-A Antibody (H-8): m-IgG2b BP-HRP Bundle | sc-548945 | 200 µg Ab; 10 µg BP | $361.00 | |||
fetuin-A Antibody (H-8) AC | sc-166531 AC | 500 µg/ml, 25% agarose | $424.00 | |||
fetuin-A Antibody (H-8) HRP | sc-166531 HRP | 200 µg/ml | $322.00 | |||
fetuin-A Antibody (H-8) FITC | sc-166531 FITC | 200 µg/ml | $336.00 | |||
fetuin-A Antibody (H-8) PE | sc-166531 PE | 200 µg/ml | $349.00 | |||
fetuin-A Antibody (H-8) Alexa Fluor® 488 | sc-166531 AF488 | 200 µg/ml | $364.00 | |||
fetuin-A Antibody (H-8) Alexa Fluor® 546 | sc-166531 AF546 | 200 µg/ml | $364.00 | |||
fetuin-A Antibody (H-8) Alexa Fluor® 594 | sc-166531 AF594 | 200 µg/ml | $364.00 | |||
fetuin-A Antibody (H-8) Alexa Fluor® 647 | sc-166531 AF647 | 200 µg/ml | $364.00 | |||
fetuin-A Antibody (H-8) Alexa Fluor® 680 | sc-166531 AF680 | 200 µg/ml | $364.00 | |||
fetuin-A Antibody (H-8) Alexa Fluor® 790 | sc-166531 AF790 | 200 µg/ml | $364.00 |