FBL8 Antibody (D-1): sc-390582
- FBL8 Antibody (D-1) is a mouse monoclonal IgG2b κ FBL8 antibody, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 274-298 of FBL8 of human origin
- FBL8 Antibody (D-1) is recommended for detection of FBL8 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-FBL8 Antibody (D-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for FBL8 Antibody (D-1) for WB applications. These reagents are now offered in bundles with FBL8 Antibody (D-1) (see ordering information below).
FBL8 Antibody (D-1) is a mouse monoclonal IgG2b kappa light chain antibody that detects FBL8 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FBL8 Antibody (D-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FBL8, also known as F-box/LRR-repeat protein 8, consists of 374 amino acids and is encoded by the human gene FBXL8. FBL8 features a distinct F-box domain, which is crucial for its role in the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex, facilitating the recognition and recruitment of substrates for ubiquitination. FBL8 regulates various cellular processes, including the cell cycle and immune responses, by targeting key proteins such as cyclins and β-catenin for proteasomal degradation. Additionally, FBL8 is involved in post-translational modifications that can influence interactions and functional outcomes, making FBL8 a vital component in maintaining cellular homeostasis and signaling pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
FBL8 Antibody (D-1) References:
- Identification of a family of human F-box proteins. | Cenciarelli, C., et al. 1999. Curr Biol. 9: 1177-9. PMID: 10531035
- A family of mammalian F-box proteins. | Winston, JT., et al. 1999. Curr Biol. 9: 1180-2. PMID: 10531037
- The F-box: a new motif for ubiquitin dependent proteolysis in cell cycle regulation and signal transduction. | Craig, KL. and Tyers, M. 1999. Prog Biophys Mol Biol. 72: 299-328. PMID: 10581972
- cDNA cloning and expression analysis of new members of the mammalian F-box protein family. | Ilyin, GP., et al. 2000. Genomics. 67: 40-7. PMID: 10945468
- Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex. | Schulman, BA., et al. 2000. Nature. 408: 381-6. PMID: 11099048
- A new subfamily of structurally related human F-box proteins. | Ilyin, GP., et al. 2002. Gene. 296: 11-20. PMID: 12383498
- The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro. | Winston, JT., et al. 1999. Genes Dev. 13: 270-83. PMID: 9990852
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FBL8 Antibody (D-1) | sc-390582 | 200 µg/ml | $316.00 | |||
FBL8 Antibody (D-1): m-IgGκ BP-HRP Bundle | sc-523590 | 200 µg Ab, 40 µg BP | $354.00 | |||
FBL8 Antibody (D-1): m-IgG2b BP-HRP Bundle | sc-549128 | 200 µg Ab; 10 µg BP | $354.00 | |||
FBL8 Antibody (D-1) AC | sc-390582 AC | 500 µg/ml, 25% agarose | $416.00 | |||
FBL8 Antibody (D-1) HRP | sc-390582 HRP | 200 µg/ml | $316.00 | |||
FBL8 Antibody (D-1) FITC | sc-390582 FITC | 200 µg/ml | $330.00 | |||
FBL8 Antibody (D-1) PE | sc-390582 PE | 200 µg/ml | $343.00 | |||
FBL8 Antibody (D-1) Alexa Fluor® 488 | sc-390582 AF488 | 200 µg/ml | $357.00 | |||
FBL8 Antibody (D-1) Alexa Fluor® 546 | sc-390582 AF546 | 200 µg/ml | $357.00 | |||
FBL8 Antibody (D-1) Alexa Fluor® 594 | sc-390582 AF594 | 200 µg/ml | $357.00 | |||
FBL8 Antibody (D-1) Alexa Fluor® 647 | sc-390582 AF647 | 200 µg/ml | $357.00 | |||
FBL8 Antibody (D-1) Alexa Fluor® 680 | sc-390582 AF680 | 200 µg/ml | $357.00 | |||
FBL8 Antibody (D-1) Alexa Fluor® 790 | sc-390582 AF790 | 200 µg/ml | $357.00 | |||
FBL8 (D-1) Neutralizing Peptide | sc-390582 P | 100 µg/0.5 ml | $68.00 |