FANCL Antibody (H-8): sc-137068
- FANCL Antibody (H-8) is a mouse monoclonal mouse IgG2b κ κ provided at 200 µg/ml
- raised against amino acids 76-375 mapping at the C-terminus of FANCL of human origin
- recommended for detection of FANCL of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP and m-IgG2b BP-HRP are the preferred secondary detection reagents for FANCL Antibody (H-8) for WB and IHC(P) applications. These reagents are now offered in bundles with FANCL Antibody (H-8) (see ordering information below).
FANCL Antibody (H-8) is a mouse monoclonal IgG2b antibody that detects FANCL in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). FANCL plays a crucial role in the Fanconi anemia (FA) pathway, which is essential for maintaining genomic stability and preventing chromosomal breakage. FANCL (H-8) antibody recognizes a protein that functions as a ligase, mediating the ubiquitination of FANCD2, a vital step in the cellular response to DNA damage. FANCL (H-8) monoclonal antibody enables research into a protein where defects can lead to Fanconi anemia, an autosomal recessive disorder characterized by bone marrow failure, developmental abnormalities, and increased susceptibility to cancer due to chromosomal instability. Additionally, phosphorylation of FANCL and other FA proteins is believed to be critical for their activity, facilitating the monoubiquitination of FANCD2 and its subsequent colocalization with BRCA1 in nuclear foci, which is essential for effective DNA repair. Anti-FANCL antibody (H-8) serves as an invaluable tool for researchers studying the mechanisms of DNA damage response and the implications of FA in human health.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FANCL Antibody (H-8) | sc-137068 | 200 µg/ml | $322.00 | |||
FANCL Antibody (H-8): m-IgG Fc BP-HRP Bundle | sc-539927 | 200 µg Ab; 10 µg BP | $361.00 | |||
FANCL Antibody (H-8): m-IgG2b BP-HRP Bundle | sc-549755 | 200 µg Ab; 10 µg BP | $361.00 |