FANCL Antibody (B-11): sc-137067
- FANCL Antibody (B-11) is a mouse monoclonal IgG2b κ, cited in 5 publications, provided at 200 µg/ml
- raised against amino acids 76-375 mapping at the C-terminus of FANCL of human origin
- Anti-FANCL Antibody (B-11) is recommended for detection of FANCL of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-FANCL Antibody (B-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for FANCL Antibody (B-11) for WB and IHC(P) applications. These reagents are now offered in bundles with FANCL Antibody (B-11) (see ordering information below).
FANCL Antibody (B-11) is a mouse monoclonal IgG2b kappa light chain antibody that detects FANCL in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). FANCL (B-11) antibody is available in non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FANCL plays a crucial role in the Fanconi anemia (FA) pathway, which is essential for maintaining genomic stability. Defects in FANCL can lead to Fanconi anemia, an autosomal recessive disorder characterized by bone marrow failure, developmental abnormalities, and increased susceptibility to chromosomal breakage. FANCL functions as a ligase, mediating the ubiquitination of FANCD2, a pivotal step in the DNA damage response. This ubiquitination is vital for the recruitment of repair proteins to sites of DNA damage, thereby facilitating the repair process. Additionally, phosphorylation of FANCL and other FA proteins is believed to be critical for their function within the FA pathway, highlighting the importance of post-translational modifications in regulating protein interactions and activities. FANCL may also be necessary for proper primordial germ cell proliferation during embryonic development, underscoring its significance in both DNA repair and developmental processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
FANCL Antibody (B-11) References:
- A novel ubiquitin ligase is deficient in Fanconi anemia. | Meetei, AR., et al. 2003. Nat Genet. 35: 165-70. PMID: 12973351
- The Fanconi anemia core complex associates with chromatin during S phase. | Mi, J. and Kupfer, GM. 2005. Blood. 105: 759-66. PMID: 15256425
- X-linked inheritance of Fanconi anemia complementation group B. | Meetei, AR., et al. 2004. Nat Genet. 36: 1219-24. PMID: 15502827
- Fanconi anemia in Ashkenazi Jews. | Kutler, DI. and Auerbach, AD. 2004. Fam Cancer. 3: 241-8. PMID: 15516848
- New advances in the DNA damage response network of Fanconi anemia and BRCA proteins. FAAP95 replaces BRCA2 as the true FANCB protein. | Fei, P., et al. 2005. Cell Cycle. 4: 80-6. PMID: 15611632
- A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M. | Meetei, AR., et al. 2005. Nat Genet. 37: 958-63. PMID: 16116422
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FANCL Antibody (B-11) | sc-137067 | 200 µg/ml | $322.00 | |||
FANCL Antibody (B-11): m-IgGκ BP-HRP Bundle | sc-521413 | 200 µg Ab, 40 µg BP | $361.00 | |||
FANCL Antibody (B-11): m-IgG2b BP-HRP Bundle | sc-548891 | 200 µg Ab; 10 µg BP | $361.00 | |||
FANCL Antibody (B-11) AC | sc-137067 AC | 500 µg/ml, 25% agarose | $424.00 | |||
FANCL Antibody (B-11) HRP | sc-137067 HRP | 200 µg/ml | $322.00 | |||
FANCL Antibody (B-11) FITC | sc-137067 FITC | 200 µg/ml | $336.00 | |||
FANCL Antibody (B-11) PE | sc-137067 PE | 200 µg/ml | $349.00 | |||
FANCL Antibody (B-11) Alexa Fluor® 488 | sc-137067 AF488 | 200 µg/ml | $364.00 | |||
FANCL Antibody (B-11) Alexa Fluor® 546 | sc-137067 AF546 | 200 µg/ml | $364.00 | |||
FANCL Antibody (B-11) Alexa Fluor® 594 | sc-137067 AF594 | 200 µg/ml | $364.00 | |||
FANCL Antibody (B-11) Alexa Fluor® 647 | sc-137067 AF647 | 200 µg/ml | $364.00 | |||
FANCL Antibody (B-11) Alexa Fluor® 680 | sc-137067 AF680 | 200 µg/ml | $364.00 | |||
FANCL Antibody (B-11) Alexa Fluor® 790 | sc-137067 AF790 | 200 µg/ml | $364.00 |