FANCL Antibody (C-4): sc-137076
- FANCL Antibody (C-4) is a mouse monoclonal IgG2b κ FANCL antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 76-375 mapping at the C-terminus of FANCL of human origin
- FANCL Antibody (C-4) is recommended for detection of FANCL of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-FANCL Antibody (C-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for FANCL Antibody (C-4) for WB and IHC(P) applications. These reagents are now offered in bundles with FANCL Antibody (C-4) (see ordering information below).
FANCL Antibody (C-4) is a mouse monoclonal IgG2b kappa light chain antibody that detects FANCL protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-FANCL antibody (C-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FANCL protein plays a crucial role in the Fanconi anemia (FA) pathway, which is essential for maintaining genomic stability. Specifically, FANCL functions as a ligase that mediates the ubiquitination of FANCD2, a critical step in the DNA damage response. This ubiquitination is vital for the recruitment of repair proteins to sites of DNA damage, thereby facilitating the repair process and preventing chromosomal instability. Defects in FANCL can lead to Fanconi anemia, an autosomal recessive disorder characterized by bone marrow failure, developmental abnormalities, and increased susceptibility to cancer due to impaired DNA repair mechanisms. The phosphorylation of FANCL and other FA proteins is also significant, as phosphorylation regulates their activity and interactions within the pathway, underscoring the importance of post-translational modifications in the function of the FA pathway.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FANCL Antibody (C-4) | sc-137076 | 200 µg/ml | $322.00 | |||
FANCL Antibody (C-4): m-IgGκ BP-HRP Bundle | sc-521417 | 200 µg Ab, 40 µg BP | $361.00 | |||
FANCL Antibody (C-4): m-IgG2b BP-HRP Bundle | sc-548893 | 200 µg Ab; 10 µg BP | $361.00 | |||
FANCL Antibody (C-4) AC | sc-137076 AC | 500 µg/ml, 25% agarose | $424.00 | |||
FANCL Antibody (C-4) HRP | sc-137076 HRP | 200 µg/ml | $322.00 | |||
FANCL Antibody (C-4) FITC | sc-137076 FITC | 200 µg/ml | $336.00 | |||
FANCL Antibody (C-4) PE | sc-137076 PE | 200 µg/ml | $349.00 | |||
FANCL Antibody (C-4) Alexa Fluor® 488 | sc-137076 AF488 | 200 µg/ml | $364.00 | |||
FANCL Antibody (C-4) Alexa Fluor® 546 | sc-137076 AF546 | 200 µg/ml | $364.00 | |||
FANCL Antibody (C-4) Alexa Fluor® 594 | sc-137076 AF594 | 200 µg/ml | $364.00 | |||
FANCL Antibody (C-4) Alexa Fluor® 647 | sc-137076 AF647 | 200 µg/ml | $364.00 | |||
FANCL Antibody (C-4) Alexa Fluor® 680 | sc-137076 AF680 | 200 µg/ml | $364.00 | |||
FANCL Antibody (C-4) Alexa Fluor® 790 | sc-137076 AF790 | 200 µg/ml | $364.00 |