Factor H Antibody (L20/3): sc-47686
- Factor H Antibody (L20/3) is a mouse monoclonal IgG1 κ, cited in 4 publications, provided at 200 µg/ml
- raised against complement protein factor H purified from human serum
- recommended for detection of Factor H of human origin by WB, IP, IF and IHC(P)
- See Factor H (C18/3): sc-47685 for Factor H antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Factor H Antibody (L20/3) for WB and IHC(P) applications. These reagents are now offered in bundles with Factor H Antibody (L20/3) (see ordering information below).
QUICK LINKS
SEE ALSO...
Factor H Antibody (L20/3) is a mouse monoclonal IgG1 antibody that detects Factor H in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Factor H is a crucial serum glycoprotein composed of 1213 amino acids, organized into 20 short consensus repeats (SCRs) that are approximately 60 amino acids in length, along with an 18-residue leader sequence. This unique structure allows Factor H to effectively regulate the alternative complement pathway, serving as a cofactor for Factor I, which inactivates C3b, thereby preventing excessive complement activation that could lead to tissue damage. Beyond complement system regulation, Factor H also interacts with various cellular components, including the integrin receptor CD11b/CD18 and cell surface glycosaminoglycans, highlighting Factor H′s multifunctional nature and importance in immune response and pathogen recognition. Notably, Factor H deficiencies are associated with acute renal diseases, underscoring Factor H′s significance in maintaining kidney health and overall immune function. Anti-Factor H antibody (L20/3) is an essential tool for researchers investigating the complexities of the complement system and its implications in various diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Factor H Antibody (L20/3) References:
- Factor H and the pathogenesis of renal diseases. | Ault, BH. 2000. Pediatr Nephrol. 14: 1045-53. PMID: 10975323
- Complement factor H in its alternative identity as adrenomedullin-binding protein 1. | Sim, RB., et al. 2015. Mol Immunol. 68: 45-8. PMID: 26597206
- Complement factor H in host defense and immune evasion. | Parente, R., et al. 2017. Cell Mol Life Sci. 74: 1605-1624. PMID: 27942748
- Potential influences of complement factor H in autoimmune inflammatory and thrombotic disorders. | Ferluga, J., et al. 2017. Mol Immunol. 84: 84-106. PMID: 28216098
- Factor H Family Proteins in Complement Evasion of Microorganisms. | Józsi, M. 2017. Front Immunol. 8: 571. PMID: 28572805
- Function and Dysfunction of Complement Factor H During Formation of Lipid-Rich Deposits. | Meri, S. and Haapasalo, K. 2020. Front Immunol. 11: 611830. PMID: 33363547
- Factor H Autoantibodies and Complement-Mediated Diseases. | Zhang, Y., et al. 2020. Front Immunol. 11: 607211. PMID: 33384694
- Hijacking Factor H for Complement Immune Evasion. | Moore, SR., et al. 2021. Front Immunol. 12: 602277. PMID: 33717083
- Factor H preserves alternative complement function during ARDS, linked to improved survival. | Bain, W., et al. 2023. ERJ Open Res. 9: PMID: 37377659
- Protective role of complement factor H against the development of preeclampsia. | Yasmin, H., et al. 2024. Front Immunol. 15: 1351898. PMID: 38464530
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Factor H Antibody (L20/3) | sc-47686 | 200 µg/ml | $316.00 | |||
Factor H Antibody (L20/3): m-IgG Fc BP-HRP Bundle | sc-536797 | 200 µg Ab; 10 µg BP | $354.00 | |||
Factor H Antibody (L20/3): m-IgGκ BP-HRP Bundle | sc-533961 | 200 µg Ab; 40 µg BP | $354.00 | |||
Factor H Antibody (L20/3): m-IgG1 BP-HRP Bundle | sc-544823 | 200 µg Ab; 20 µg BP | $354.00 |