Factor H Activators

Factor H activators are a distinct class of molecules with a primary function in the regulation of the complement system, a crucial part of the innate immune response. The complement system consists of a cascade of proteins that play a pivotal role in identifying and eliminating foreign invaders, such as bacteria and viruses, as well as damaged host cells. However, uncontrolled complement activation can lead to tissue damage and autoimmune diseases. Factor H activators are specifically involved in modulating the activity of Factor H, a key regulatory protein in the complement system.

Factor H, a glycoprotein predominantly synthesized in the liver, is responsible for downregulating the complement cascade by promoting the decay of C3b, a central complement component, on self-cells and surfaces. Factor H activators are molecules or proteins that interact with Factor H to enhance its regulatory activity. These activators help maintain the delicate balance between complement activation for defense against pathogens and the protection of host cells and tissues. By supporting Factor H in its regulatory role, Factor H activators contribute to preventing excessive complement-mediated damage to healthy cells and tissues, which is particularly important in preventing autoimmune diseases and controlling inflammation. Understanding the mechanisms and functions of Factor H activators provides valuable insights into the complex regulation of the complement system and its role in maintaining immune homeostasis.