Factor B Antibody (P21/15): sc-47679
- Factor B Antibody (P21/15) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
- raised against complement protein factor B purified from human serum
- recommended for detection of Complement Factor B Ba Fragment of human origin by WB and IP
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Factor B Antibody (P21/15) for WB applications. These reagents are now offered in bundles with Factor B Antibody (P21/15) (see ordering information below).
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Factor B Antibody (P21/15) is a mouse monoclonal IgG2a antibody that detects Factor B in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). Factor B plays a crucial role in the alternative pathway of the complement system, where Factor D cleaves Factor B into two fragments, Ba and Bb. The Bb fragment combines with complement Factor 3b to form the C3 or C5 convertase, which is essential for amplifying the complement response. This process supports the differentiation and proliferation of preactivated B lymphocytes, as well as the lysis of erythrocytes and stimulation of lymphocyte blastogenesis. Ba serves an important regulatory function by inhibiting the proliferation of preactivated B lymphocytes, thereby maintaining immune homeostasis. The intricate balance of these interactions underscores Factor B′s importance in immune responses and potential implications in various diseases, including autoimmune disorders and infections. Anti-Factor B antibody (P21/15) serves as an invaluable tool for researchers exploring the complexities of the complement system and its role in human health and disease.
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Factor B Antibody (P21/15) References:
- Dysregulation of positive transcription elongation factor B and myocardial hypertrophy. | Rice, AP. 2009. Circ Res. 104: 1327-9. PMID: 19542017
- Vascular endothelial growth factor-B in physiology and disease. | Bry, M., et al. 2014. Physiol Rev. 94: 779-94. PMID: 24987005
- The role of vascular endothelial growth factor-B in metabolic homoeostasis: current evidence. | Zafar, MI., et al. 2017. Biosci Rep. 37: PMID: 28798193
- Small-molecule factor B inhibitor for the treatment of complement-mediated diseases. | Schubart, A., et al. 2019. Proc Natl Acad Sci U S A. 116: 7926-7931. PMID: 30926668
- Factor B and C4b2a Autoantibodies in C3 Glomerulopathy. | Hauer, JJ., et al. 2019. Front Immunol. 10: 668. PMID: 31024533
- Factor B inhibition for paroxysmal nocturnal haemoglobinuria. | Brodsky, RA. 2021. Lancet Haematol. 8: e309-e310. PMID: 33765418
- Complement factor B inhibitor LNP023 improves lupus nephritis in MRL/lpr mice. | Chen, K., et al. 2022. Biomed Pharmacother. 153: 113433. PMID: 36076550
- Factor B Mutation in Monozygotic Twins Discordant for Atypical Hemolytic Uremic Syndrome. | Aradottir, SS., et al. 2023. Kidney Int Rep. 8: 1097-1101. PMID: 37180503
- Factor B inhibitor iptacopan for the treatment of paroxysmal nocturnal hemoglobinuria. | Xu, B., et al. 2024. Blood Rev. 66: 101210. PMID: 38811284
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Factor B Antibody (P21/15) | sc-47679 | 200 µg/ml | $316.00 | |||
Factor B Antibody (P21/15): m-IgG Fc BP-HRP Bundle | sc-536794 | 200 µg Ab; 10 µg BP | $354.00 | |||
Factor B Antibody (P21/15): m-IgGκ BP-HRP Bundle | sc-533958 | 200 µg Ab; 40 µg BP | $354.00 |