Factor B Antibody (M13/12): sc-47682

Factor B Antibody (M13/12) is a mouse monoclonal IgG1 antibody that detects Factor B in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). Factor B (M13/12) antibody recognizes a protein that plays a crucial role in the alternative pathway of the complement system, where Factor B is cleaved by Factor D into two fragments, Ba and Bb. The Bb fragment is essential for forming the C3 and C5 convertases, which are pivotal in amplifying the complement response and facilitating the lysis of pathogens. This process is vital for the immune system, as Factor B enhances the ability to clear infections and modulate inflammatory responses. Additionally, Factor B is involved in the differentiation and proliferation of preactivated B lymphocytes, which are critical for adaptive immunity. The Ba fragment has been shown to inhibit the proliferation of these B lymphocytes, highlighting the regulatory balance that Factor B maintains within the immune system. Understanding Factor B and its interactions within the complement pathway is important for developing therapeutic strategies for diseases where complement dysregulation plays a role, such as autoimmune disorders and chronic inflammatory conditions. Anti-Factor B antibody (M13/12) is an invaluable tool for researchers studying these complex immune mechanisms.

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Factor B Antibody (M13/12) References:

1. Platelet-derived growth factor-B gene delivery sustains gingival fibroblast signal transduction.  |  Lin, Z., et al. 2008. J Periodontal Res. 43: 440-9. PMID: 18823454
2. Access to the complement factor B scissile bond is facilitated by association of factor B with C3b protein.  |  Hourcade, DE. and Mitchell, LM. 2011. J Biol Chem. 286: 35725-35732. PMID: 21862585
3. Endothelial fatty acid transport: role of vascular endothelial growth factor B.  |  Hagberg, C., et al. 2013. Physiology (Bethesda). 28: 125-34. PMID: 23455771
4. Vascular endothelial growth factor-B expression in postischemic rat brain.  |  Xie, L., et al. 2013. Vasc Cell. 5: 8. PMID: 23601533
5. Complement factor B activation in patients with preeclampsia.  |  Velickovic, I., et al. 2015. J Reprod Immunol. 109: 94-100. PMID: 25604034
6. Vascular Endothelial Growth Factor-B Induces a Distinct Electrophysiological Phenotype in Mouse Heart.  |  Naumenko, N., et al. 2017. Front Physiol. 8: 373. PMID: 28620319
7. Platelet-derived growth factor B attenuates lethal sepsis through inhibition of inflammatory responses.  |  Wang, M., et al. 2019. Int Immunopharmacol. 75: 105792. PMID: 31386981
8. Complement factor B knockdown by short hairpin RNA inhibits laser-induced choroidal neovascularization in rats.  |  Wang, X., et al. 2020. Int J Ophthalmol. 13: 382-389. PMID: 32309173
9. A small fragment of factor B as a potential inhibitor of complement alternative pathway activity.  |  Sultan, EY., et al. 2021. Immunobiology. 226: 152106. PMID: 34147816
10. Experimentally Induced Anti-Myeloperoxidase Vasculitis Is Not Attenuated in Factor B or VISTA Deficient Mice.  |  Flórez-Barrós, F., et al. 2022. Glomerular Dis. 2: 83-88. PMID: 36751530

The preferred Factor B antibody is Factor B Antibody (F-7): sc-271636.