Ezrin Antibody (E-8): sc-398807

Ezrin Antibody (E-8) is a mouse monoclonal IgG1 antibody that detects Ezrin in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Ezrin is a crucial member of the ERM (Ezrin, Radixin, Moesin) protein family, which plays a significant role in linking the cytoskeleton to the plasma membrane, thereby facilitating cellular processes such as cell shape maintenance, motility, and signaling. Ezrin is primarily localized beneath the plasma membrane, where Ezrin acts as a scaffold for the assembly of signaling complexes, influencing cellular responses to external stimuli. Notably, Ezrin is a major substrate for various protein-tyrosine kinases, including the epidermal growth factor receptor, which underscores Ezrin′s importance in signal transduction pathways that regulate cell growth and differentiation. Additionally, Ezrin functions as an anchoring protein for cAMP-dependent protein kinase, designated as AKAP78, further highlighting Ezrin′s role in coordinating intracellular signaling. The distinct phosphorylation patterns of Ezrin, in comparison to its homologs Moesin and Radixin, suggest that Ezrin may have unique regulatory mechanisms and functional implications in different cellular contexts. With versatile applications and critical role in cellular dynamics, anti-Ezrin antibody (E-8) is an essential tool for researchers studying cytoskeletal interactions and signaling pathways.

The preferred Ezrin antibody is Ezrin Antibody (3C12): sc-58758.