Ezrin Antibody (A-4): sc-271456

Ezrin Antibody (A-4) is a mouse monoclonal IgG1 antibody that detects Ezrin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Ezrin is a crucial member of the ERM (ezrin, radixin, moesin) protein family, which plays a vital role in linking the cytoskeleton to the plasma membrane, thereby facilitating cellular processes such as cell shape maintenance, motility, and signaling. Ezrin (A-4) antibody targets proteins predominantly localized beneath the plasma membrane, where Ezrin acts as a scaffold for various signaling molecules, including protein-tyrosine kinases and phosphatases, which are essential for regulating cellular responses to external stimuli. Notably, anti-Ezrin antibody (A-4) recognizes a significant substrate for several protein-tyrosine kinases, including the epidermal growth factor receptor, highlighting Ezrin′s importance in signal transduction pathways that govern cell proliferation and differentiation. Additionally, Ezrin functions as an anchoring protein for cAMP-dependent protein kinase, designated as AKAP78, which underscores Ezrin′s role in coordinating multiple signaling cascades within the cell. The unique phosphorylation patterns exhibited by Ezrin, in contrast to homologs Moesin and Radixin, further emphasize specific regulatory functions in various cellular contexts. With diverse applications and critical role in cellular dynamics, Ezrin monoclonal antibody (A-4) serves as an invaluable tool for researchers studying cytoskeletal organization and signaling pathways in health and disease.

The preferred Ezrin antibody is Ezrin Antibody (3C12): sc-58758.