EVL Antibody (G-2): sc-365751

EVL Antibody (G-2) is a mouse monoclonal IgG1 antibody that detects EVL (Ena/VASP-like protein) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). EVL is a crucial actin-binding protein that plays a significant role in cell motility and cytoskeletal organization, as EVL is expressed in filopodial tips and localizes to the edges of lamellipodia and focal adhesions. EVL contains an N-terminal EVH1 domain, a proline-rich core, and a C-terminal EVH2 domain, which are essential for interactions with other proteins. Notably, EVL interacts with the SH3 domain of spectrin a II and the LIM domain of TES through its proline-rich region, highlighting EVL′s importance in cellular signaling pathways. The structural features of EVL, particularly EVH domains, are vital for regulating actin dynamics, which is critical for processes such as growth cone motility and axon guidance in the developing nervous system. The close relationship between EVL, VASP, and Mena underscores their collective involvement in maintaining cellular architecture and facilitating movement, making anti-EVL antibody (G-2) an invaluable tool for researchers studying cytoskeletal dynamics and related cellular processes.

The preferred EVL antibody is EVL Antibody (C-12): sc-373793.