EVL Activators
The chemicals provided are potential indirect activators or influencers of EVL (Ena/VASP-like protein) activity. EVL's role in actin cytoskeleton remodeling makes it sensitive to alterations in actin dynamics and related signaling pathways. Compounds like Cytochalasin D, Latrunculin A, Jasplakinolide, and Phalloidin directly modulate actin filament organization. Cytochalasin D and Latrunculin A disrupt actin polymerization, while Jasplakinolide and Phalloidin stabilize actin filaments. These alterations in actin dynamics can indirectly affect EVL's function in actin remodeling. Inhibitors of cytoskeletal regulators such as Y-27632 (ROCK inhibitor), Blebbistatin (myosin II inhibitor), ML-7 (myosin light chain kinase inhibitor), and CK-666 (Arp2/3 complex inhibitor) can influence EVL activity by altering the cellular machinery involved in motility and structure.
Forskolin, by increasing intracellular cAMP levels, might indirectly affect EVL through cAMP-dependent pathways that regulate the cytoskeleton. Similarly, compounds like Wiskostatin and SMIFH2, which inhibit N-WASP and formin-mediated actin assembly respectively, could indirectly influence EVL's role in actin dynamics. Cucurbitacin I, known to disrupt both actin and microtubule dynamics, might also have indirect implications for EVL function. These potential indirect activators or influencers of EVL provide various mechanisms to impact its activity, primarily focusing on the regulation of actin cytoskeleton and related cellular processes. Each compound offers a unique approach to modulate the cellular environment where EVL operates, potentially influencing its roles in cell migration, adhesion, and cytoskeletal remodeling.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $180.00 $299.00 | 59 | |
A compound that stabilizes actin filaments, potentially influencing EVL function in cytoskeletal remodeling. | ||||||
Phalloidin | 17466-45-4 | sc-202763 | 1 mg | $229.00 | 33 | |
A toxin that stabilizes actin filaments, which might affect EVL function. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
A ROCK inhibitor, known to affect cytoskeletal dynamics, could have implications for EVL activity. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $71.00 $260.00 $485.00 $949.00 | ||
An inhibitor of myosin II, which might influence EVL by altering cellular contractility and motility. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
By increasing cAMP, Forskolin may indirectly influence EVL through cAMP-dependent pathways affecting the cytoskeleton. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
An inhibitor of N-WASP, a regulator of actin polymerization, potentially affecting EVL's function in actin dynamics. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
An inhibitor of formin-mediated actin assembly, which might have implications for EVL function. | ||||||
Cucurbitacin I | 2222-07-3 | sc-203010 | 1 mg | $250.00 | 9 | |
Disrupts actin and microtubule dynamics, potentially impacting EVL. | ||||||