ETAR Antibody (D-2): sc-518060

ETAR Antibody (D-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects Endothelin Receptor Type A (ETAR) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ETAR (D-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Endothelin receptor A (ETAR), also known as EDNRA, ET1 Receptor, ETA, EDN1, and ET-AR, is a crucial member of the guanine-binding regulatory protein-coupled receptor family, primarily responsible for mediating endothelin effects, particularly endothelin-1 (ET1), which binds with highest affinity compared to endothelin B receptor (ETBR). ETAR activation plays a significant role in various physiological processes, including vascular tone and blood pressure regulation, leading to increased cytoplasmic calcium concentration in cultured lens epithelial cells and inducing arachidonic acid accumulation. ETAR is characterized by seven hydrophobic transmembrane domains and is predominantly expressed in tissues such as aorta, lung, atrium, kidney, placenta, and prostate, with placental vascular smooth muscle cells (PVSMCs) being a unique site of exclusive expression. ETAR localization and function understanding is vital, as dysregulation is implicated in various cardiovascular diseases and conditions related to abnormal vascular function.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ETAR Antibody (D-2) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-ETAR Antibody (D-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ETAR Antibody (D-2) Specifications

Alternate Product Name: Endothelin Receptor Type A

Product Clone Name: D-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 21-80

Epitope Target: ETAR

Epitope Species: mouse

Product Reactivity/Detection: ETAR

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for ETAR Antibody (D-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred ETAR antibody is ETAR Antibody (F-12): sc-515948.