ERp72 Antibody (C-7): sc-376230
- ERp72 Antibody (C-7) is a mouse monoclonal IgG2a κ, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 257-528 mapping within an internal region of ERp72 of human origin
- recommended for detection of ERp72 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for ERp72 Antibody (C-7) for WB and IHC(P) applications. This reagent is now offered in a bundle with ERp72 Antibody (C-7) (see ordering information below).
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ERp72 Antibody (C-7) is a mouse monoclonal IgG2a antibody that detects ERp72 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). ERp72, also known as protein disulfide-isomerase A4, plays a crucial role in the endoplasmic reticulum by facilitating proper folding and assembly of proteins, which is essential for maintaining cellular homeostasis and function. ERp72 is particularly important in the context of the major histocompatibility complex (MHC) class I pathway, where ERp72 assists in the rearrangement of disulfide bonds, ensuring that MHC class I molecules are correctly folded before presenting antigens to cytotoxic T lymphocytes. ERp72 interaction with other chaperones and proteins in the ER is vital for the immune response, as ERp72 directly influences the efficiency of antigen presentation and subsequent activation of T cells. Anti-ERp72 antibody (C-7) enables researchers to gain insights into the mechanisms of immune response and the role of protein folding in disease states, making anti-ERp72 antibody (C-7) an invaluable tool for studies in immunology and cell biology.
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ERp72 Antibody (C-7) References:
- The disulfide isomerase ERp72 supports arterial thrombosis in mice. | Zhou, J., et al. 2017. Blood. 130: 817-828. PMID: 28576878
- A humanized monoclonal antibody that inhibits platelet-surface ERp72 reveals a role for ERp72 in thrombosis. | Holbrook, LM., et al. 2018. J Thromb Haemost. 16: 367-377. PMID: 29052936
- Functional Interplay between P5 and PDI/ERp72 to Drive Protein Folding. | Matsusaki, M., et al. 2021. Biology (Basel). 10: PMID: 34827105
- A novel role for endoplasmic reticulum protein ERp72 in the pathogenesis of autoantibody-induced arthritis. | Yang, A., et al. 2025. Scand J Rheumatol. 54: 16-24. PMID: 38975658
- Several endoplasmic reticulum stress proteins, including ERp72, interact with thyroglobulin during its maturation. | Kuznetsov, G., et al. 1994. J Biol Chem. 269: 22990-5. PMID: 7916014
- Identification of genomic sequences that mediate the induction of the endoplasmic reticulum stress protein, ERp72, by protein traffic. | Srinivasan, M., et al. 1993. DNA Cell Biol. 12: 807-22. PMID: 8216852
- Serum antibodies from halothane hepatitis patients react with the rat endoplasmic reticulum protein ERp72. | Pumford, NR., et al. 1993. Chem Res Toxicol. 6: 609-15. PMID: 8292737
- Effects of CaBP2, the rat analog of ERp72, and of CaBP1 on the refolding of denatured reduced proteins. Comparison with protein disulfide isomerase. | Rupp, K., et al. 1994. J Biol Chem. 269: 2501-7. PMID: 8300576
- CaBP2 is a rat homolog of ERp72 with proteindisulfide isomerase activity. | Van, PN., et al. 1993. Eur J Biochem. 213: 789-95. PMID: 8477750
- Erp72 expression activated by transient cerebral ischemia or disturbance of neuronal endoplasmic reticulum calcium stores. | Paschen, W., et al. 1998. Metab Brain Dis. 13: 55-68. PMID: 9570640
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ERp72 Antibody (C-7) | sc-376230 | 200 µg/ml | $322.00 | |||
ERp72 Antibody (C-7): m-IgG Fc BP-HRP Bundle | sc-540533 | 200 µg Ab; 10 µg BP | $361.00 |