ERp72 Antibody (B-2): sc-376210

ERp72 Antibody (B-2) is a mouse monoclonal IgM antibody that detects ERp72 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ERp72, also known as protein disulfide-isomerase A4, plays a crucial role in the endoplasmic reticulum by facilitating proper protein folding and disulfide bond rearrangement, which is essential for maintaining protein structure and function. Anti-ERp72 antibody (B-2) enables research into MHC class I antigen presentation pathways, where ERp72 interacts with other chaperones and proteins to ensure correct MHC class I molecule assembly before peptide presentation to cytotoxic T lymphocytes. ERp72′s ability to catalyze disulfide bond formation and rearrangement is vital for protein stability, and ERp72 dysfunction can lead to various diseases, including autoimmune disorders and cancer. ERp72 (B-2) antibody helps researchers gain insights into protein folding mechanisms and ERp72′s implications in cellular stress responses and immune regulation.

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ERp72 Antibody (B-2) References:

1. Identification of novel peptide binding proteins in the endoplasmic reticulum: ERp72, calnexin, and grp170.  |  Spee, P., et al. 1999. Biochemistry. 38: 10559-66. PMID: 10441153
2. Nascent lipidated apolipoprotein B is transported to the Golgi as an incompletely folded intermediate as probed by its association with network of endoplasmic reticulum molecular chaperones, GRP94, ERp72, BiP, calreticulin, and cyclophilin B.  |  Zhang, J. and Herscovitz, H. 2003. J Biol Chem. 278: 7459-68. PMID: 12397072
3. Molecular characterization and expression of an alfalfa protein with sequence similarity to mammalian ERp72, a glucose-regulated endoplasmic reticulum protein containing active site sequences of protein disulphide isomerase.  |  Shorrosh, BS. and Dixon, RA. 1992. Plant J. 2: 51-8. PMID: 1303795
4. An antibody that binds a neutrophil membrane protein, ERp72, primes human neutrophils for enhanced oxidative metabolism in response to formyl-methionyl-leucyl-phenylalanine. Implications for ERp72 in the signal transduction pathway for neutrophil priming.  |  Weisbart, RH. 1992. J Immunol. 148: 3958-63. PMID: 1318337
5. Oxidoreductase interactions include a role for ERp72 engagement with mutant thyroglobulin from the rdw/rdw rat dwarf.  |  Menon, S., et al. 2007. J Biol Chem. 282: 6183-91. PMID: 17200118
6. A possible biochemical link between NADPH oxidase (Nox) 1 redox-signalling and ERp72.  |  Chen, W., et al. 2008. Biochem J. 416: 55-63. PMID: 18620548
7. Structure of the catalytic a(0)a fragment of the protein disulfide isomerase ERp72.  |  Kozlov, G., et al. 2010. J Mol Biol. 401: 618-25. PMID: 20600112
8. Vascular endothelial ERp72 is involved in the inflammatory response in a rat model of skeletal muscle injury.  |  Khalaf, NB., et al. 2021. Mol Med Rep. 23: PMID: 33398381
9. NF-Y, a CCAAT box-binding protein, is one of the trans-acting factors necessary for the response of the murine ERp72 gene to protein traffic.  |  Marcus, N. and Green, M. 1997. DNA Cell Biol. 16: 1123-31. PMID: 9324314
10. Role of calcium in the activation of erp72 and heme oxygenase-1 expression on depletion of endoplasmic reticulum calcium stores in rat neuronal cell culture.  |  Linden, T., et al. 1998. Neurosci Lett. 247: 103-6. PMID: 9655603

The preferred ERp72 antibody is ERp72 Antibody (B-4): sc-390530.