ERp57 Antibody (B-5): sc-166680

ERp57 Antibody (B-5) is a mouse monoclonal IgG2b antibody that detects ERp57 in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). ERp57, also known as GRP57, GRP58, ERp60, and ERp61, plays a crucial role in the major histocompatibility complex (MHC) class I pathway, which is essential for the immune response against intracellular pathogens. ERp57 is primarily located in the endoplasmic reticulum, where ERp57 assists in the proper folding and assembly of MHC class I molecules, ensuring that MHC class I molecules can effectively present short pathogenic peptides to cytotoxic T lymphocytes. ERp57 functioning is vital for the immune system, as any disruption in this process can lead to impaired antigen presentation and a weakened immune response, making ERp57 a significant factor in the body′s defense mechanisms. The human ERp57 gene is located on chromosome 15q15 and encodes a 505 amino acid protein that contains two highly conserved Trp-Cys-Gly-His-Cys-Lys motifs, underscoring its evolutionary importance. ERp57 may also exhibit multifunctional properties, acting as a protease, a protein disulfide isomerase, or a phospholipase, which further highlights ERp57′s significance in cellular processes.

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ERp57 Antibody (B-5) References:

1. Cellular functions of endoplasmic reticulum chaperones calreticulin, calnexin, and ERp57.  |  Bedard, K., et al. 2005. Int Rev Cytol. 245: 91-121. PMID: 16125546
2. ERP57 membrane translocation dictates the immunogenicity of tumor cell death by controlling the membrane translocation of calreticulin.  |  Obeid, M. 2008. J Immunol. 181: 2533-43. PMID: 18684944
3. Green tea catechins can bind and modify ERp57/PDIA3 activity.  |  Trnková, L., et al. 2013. Biochim Biophys Acta. 1830: 2671-82. PMID: 23671928
4. Depletion of the thiol oxidoreductase ERp57 in tumor cells inhibits proliferation and increases sensitivity to ionizing radiation and chemotherapeutics.  |  Hussmann, M., et al. 2015. Oncotarget. 6: 39247-61. PMID: 26513173
5. An ERp57-mediated disulphide exchange promotes the interaction between Burkholderia cenocepacia and epithelial respiratory cells.  |  Pacello, F., et al. 2016. Sci Rep. 6: 21140. PMID: 26879174
6. Endoplasmic reticulum-resident protein 57 (ERp57) oxidatively inactivates human transglutaminase 2.  |  Yi, MC., et al. 2018. J Biol Chem. 293: 2640-2649. PMID: 29305423
7. DT-010 Exerts Cardioprotective Effects by Regulating the Crosstalk between the AMPK/PGC-1α Pathway and ERp57.  |  Zhang, X., et al. 2023. Cardiovasc Ther. 2023: 8047752. PMID: 36817353
8. Inducing Melanoma Cell Apoptosis by ERp57/PDIA3 Antibody in the Presence of CPI-613 and Hydroxychloroquine.  |  Ichiki, N., et al. 2024. J Cancer. 15: 1779-1785. PMID: 38434963
9. Protein Disulfide Isomerase Endoplasmic Reticulum Protein 57 (ERp57) is Protective Against ALS-Associated Mutant TDP-43 in Neuronal Cells.  |  Parakh, S., et al. 2024. Neuromolecular Med. 26: 23. PMID: 38861223
10. AURKC Promotes Clear Cell Renal Cell Carcinoma Proliferation Through Upregulation of ERp57.  |  Liu, Y., et al. 2025. J Cancer. 16: 1215-1227. PMID: 39895780

The preferred ERp57 antibody is ERp57 Antibody (MaP.ERp57): sc-23886.