ERK 2 Antibody (C-8): sc-271458
- ERK 2 Antibody (C-8) is a mouse monoclonal IgG2b κ, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 276-333 within subdomain XI of rat ERK 2-encoded MAP kinase p42
- recommended for detection of ERK 2 p42 of mouse, rat, human and avian origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and canine, bovine, porcine and avian
- See ERK 2 (D-2): sc-1647 for ERK 2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ERK 2 Antibody (C-8) for WB and IHC(P) applications. These reagents are now offered in bundles with ERK 2 Antibody (C-8) (see ordering information below).
QUICK LINKS
ERK 2 Antibody (C-8) is a mouse monoclonal IgG2b antibody that detects ERK 2 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). ERK2 (Extracellular Signal-Regulated Kinase 2), also known as MAPK1 or p42 MAPK, plays a crucial role in mitogen-activated protein kinase (MAPK) signaling pathways, which are essential for transmitting signals from cell surface to nucleus, thereby regulating cellular processes such as proliferation, differentiation, and survival. ERK2 protein is primarily located in cytoplasm but translocates to nucleus upon activation, where ERK2 influences gene expression by phosphorylating target proteins. This translocation is vital for modulating cellular responses to growth factors and stress signals, highlighting ERK2′s importance in maintaining cellular homeostasis and responding to external stimuli. The human ERK2 gene is located on chromosome 22q11.21 and encodes a 360-amino acid protein that undergoes specific phosphorylation at threonine and tyrosine residues, which is critical for activation and subsequent dimerization with other ERK proteins. Anti-ERK2 antibody (C-8) is an invaluable tool for researchers studying signaling pathways that govern cell behavior and underlying mechanisms of various diseases.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ERK 2 Antibody (C-8) | sc-271458 | 200 µg/ml | $316.00 | |||
ERK 2 Antibody (C-8): m-IgGκ BP-HRP Bundle | sc-534970 | 200 µg Ab; 40 µg BP | $354.00 | |||
ERK 2 Antibody (C-8): m-IgG2b BP-HRP Bundle | sc-549323 | 200 µg Ab; 10 µg BP | $354.00 | |||
ERK 2 (C-8) Neutralizing Peptide | sc-271458 P | 100 µg/0.5 ml | $68.00 |