ERK 1 Antibody (E-12): sc-271291

ERK 1 Antibody (E-12) is a mouse monoclonal IgG3 kappa light chain antibody specific for an epitope mapping between amino acids 291-335 within subdomain XI of ERK 1 of rat origin, exhibiting strong species reactivity with mouse, rat, and human proteins by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA); ERK 1 (E-12) antibody is also reactive with additional species including equine, canine, bovine, and porcine. ERK1, also known as Mitogen-activated protein kinase 3 (MAPK3), is a critical serine/threonine kinase that plays a pivotal role in the MAPK/ERK signaling pathway, which transmits extracellular signals into intracellular responses. The primary function of ERK1 is to regulate essential cellular processes such as proliferation, differentiation, survival, and development. Activation of ERK1 occurs through dual phosphorylation by upstream kinases MEK1 and MEK2 in response to stimuli like growth factors, cytokines, and mitogens. Once activated, ERK1 translocates to the nucleus where ERK1 phosphorylates a variety of substrates, including transcription factors such as ELK1, c-Fos, and c-Myc, leading to the regulation of genes involved in cell cycle progression and differentiation. The proper functioning of ERK1 is crucial because ERK1 dysregulation can result in pathological conditions, including cancer, neurodegenerative diseases, and developmental disorders. Anti-ERK 1 antibody (E-12) is an invaluable tool for researchers investigating the function of ERK1 in signal transduction pathways and its implications in health and disease.

The preferred p-ERK antibody is p-ERK Antibody (E-4): sc-7383.