ErbB4/HER4 Antibody (HFR1): sc-53280

ErbB-4 Antibody (HFR1) is a mouse monoclonal IgG2b antibody that detects ErbB-4 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. ErbB-4 is a member of the epidermal growth factor receptor family, which plays a crucial role in cell signaling pathways that regulate cell proliferation, differentiation, and survival. ErbB-4 is primarily located on the cell membrane, where ErbB-4 can form homodimers or heterodimers upon ligand binding, a process essential for activation and subsequent signaling. ErbB-4′s membrane localization enables interaction with various ligands, such as heregulin, which promotes proteolytic cleavage and ectodomain release. This ectodomain can then engage in paracrine signaling, influencing neighboring cells and contributing to tissue homeostasis and development. ErbB-4 expression is particularly high in breast carcinoma cell lines, as well as in normal tissues such as skeletal muscle, heart, pituitary, brain, and cerebellum, highlighting ErbB-4′s significance in both normal physiology and cancer biology. With robust reactivity and versatility in multiple applications, anti-ErbB-4 antibody (HFR1) is an invaluable tool for researchers studying this receptor′s intricate roles in health and disease.

The preferred ErbB4/HER4 antibody is ErbB4/HER4 Antibody (C-7): sc-8050.