epsin 1 Antibody (F-7): sc-55555
- epsin 1 Antibody (F-7) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 311-440 of epsin 1 of human origin
- recommended for detection of epsin 1 of human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for epsin 1 Antibody (F-7) for WB and IHC(P) applications. These reagents are now offered in bundles with epsin 1 Antibody (F-7) (see ordering information below).
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Epsin 1 Antibody (F-7) is a mouse monoclonal IgG1 antibody that detects Epsin 1 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Epsin 1 plays a crucial role in the endocytic process, particularly in the formation of Clathrin-coated vesicles, which are essential for the internalization of membrane proteins and lipids. Epsin 1 is primarily located at the leading edge of vesicular coated pits, where Epsin 1 facilitates the bending of the membrane, a critical step in endocytosis. The presence of an epsin N-terminal homology (ENTH) domain and a Clathrin-binding motif within Epsin 1 underscores Epsin 1′s importance in the recruitment of Clathrin and other accessory proteins, thereby regulating the dynamics of vesicle formation. Additionally, Epsin 1 undergoes post-translational modifications, including phosphorylation, which can influence Epsin 1′s interaction with other proteins and functional activity during cellular processes. Epsin 1′s ability to interact with proteins such as Eps15 and Clathrin highlights Epsin 1′s integral role in the endocytic machinery, making Epsin 1 a vital component for maintaining cellular homeostasis and signaling pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
epsin 1 Antibody (F-7) References:
- Partially overlapping distribution of epsin1 and HIP1 at the synapse: analysis by immunoelectron microscopy. | Yao, PJ., et al. 2006. J Comp Neurol. 494: 368-79. PMID: 16320245
- Arabidopsis EPSIN1 plays an important role in vacuolar trafficking of soluble cargo proteins in plant cells via interactions with clathrin, AP-1, VTI11, and VSR1. | Song, J., et al. 2006. Plant Cell. 18: 2258-74. PMID: 16905657
- Eps15 and Epsin1 are crucial for enteropathogenic Escherichia coli pedestal formation despite the absence of adaptor protein 2. | Lin, AE., et al. 2011. J Infect Dis. 204: 695-703. PMID: 21810914
- Epsin1 modulates synaptic vesicle retrieval capacity at CNS synapses. | Kyung, JW., et al. 2016. Sci Rep. 6: 31997. PMID: 27557559
- Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling. | Pascolutti, R., et al. 2019. Cell Rep. 27: 3049-3061.e6. PMID: 31167147
- ENTH domain-dependent membrane remodelling. | Steinem, C. and Meinecke, M. 2021. Soft Matter. 17: 233-240. PMID: 32432576
- EPSIN1 and MTV1 define functionally overlapping but molecularly distinct trans-Golgi network subdomains in Arabidopsis. | Heinze, L., et al. 2020. Proc Natl Acad Sci U S A. 117: 25880-25889. PMID: 32989160
- Identification of Epsin1 as a regulator for hepatic lipid and glucose metabolism. | Huang, X., et al. 2023. Genes Dis. 10: 72-75. PMID: 37013064
- Epsin1-mediated exosomal sorting of Dll4 modulates the tubular-macrophage crosstalk in diabetic nephropathy. | Liu, JL., et al. 2023. Mol Ther. 31: 1451-1467. PMID: 37016580
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
epsin 1 Antibody (F-7) | sc-55555 | 200 µg/ml | $322.00 | |||
epsin 1 Antibody (F-7): m-IgG Fc BP-HRP Bundle | sc-537075 | 200 µg Ab; 10 µg BP | $361.00 | |||
epsin 1 Antibody (F-7): m-IgGκ BP-HRP Bundle | sc-534261 | 200 µg Ab; 40 µg BP | $361.00 | |||
epsin 1 Antibody (F-7): m-IgG1 BP-HRP Bundle | sc-544988 | 200 µg Ab; 20 µg BP | $361.00 |