eotaxin Antibody (G-1): sc-374233

eotaxin Antibody (G-1) is a mouse monoclonal IgG1 antibody that detects eotaxin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Eotaxin, also known as eotaxin-1, is a crucial member of the C-C or β family of chemokines, distinguished by its pair of adjacent cysteine residues, and plays a significant role in the immune response by acting as a potent chemoattractant for eosinophils. The importance of eotaxin lies in its involvement in various allergic conditions, including bronchial asthma, dermatitis, conjunctivitis, and potentially inflammatory bowel disease, where eosinophilia is a prominent feature. Eotaxin exerts its effects by binding to the CKR-3 receptor, which is expressed on the surface of primary eosinophils and is known to have high affinity for eotaxin, as well as for other chemokines like RANTES and MCP-3. Notably, CKR-3 also functions as a co-receptor for a restricted subset of viruses, highlighting the multifaceted role of eotaxin in both immune regulation and viral pathogenesis. anti-eotaxin antibody (G-1) is an essential tool for researchers studying the mechanisms of eosinophil recruitment and the underlying processes of allergic diseases.

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eotaxin Antibody (G-1) References:

1. Eotaxin: from an eosinophilic chemokine to a major regulator of allergic reactions.  |  Gutierrez-Ramos, JC., et al. 1999. Immunol Today. 20: 500-4. PMID: 10529777
2. Role of eotaxin and related CC chemokines in allergy and asthma.  |  Williams, TJ. and Jose, PJ. 2000. Chem Immunol. 78: 166-77. PMID: 12847728
3. The eotaxin chemokines and CCR3 are fundamental regulators of allergen-induced pulmonary eosinophilia.  |  Pope, SM., et al. 2005. J Immunol. 175: 5341-50. PMID: 16210640
4. Synephrine inhibits eotaxin-1 expression via the STAT6 signaling pathway.  |  Roh, KB., et al. 2014. Molecules. 19: 11883-95. PMID: 25111027
5. Eotaxin-Rich Proangiogenic Hematopoietic Progenitor Cells and CCR3+ Endothelium in the Atopic Asthmatic Response.  |  Asosingh, K., et al. 2016. J Immunol. 196: 2377-87. PMID: 26810221
6. The Importance of Intestinal Eotaxin-1 in Inflammatory Bowel Disease: New Insights and Possible Therapeutic Implications.  |  Adar, T., et al. 2016. Dig Dis Sci. 61: 1915-24. PMID: 26874691
7. Role of eotaxin-1/CCL11 in sepsis-induced myocardial injury in elderly patients.  |  Li, Y., et al. 2020. Aging (Albany NY). 12: 4463-4473. PMID: 32147601
8. Reduced ccl11/eotaxin mediates the beneficial effects of environmental stimulation on the aged hippocampus.  |  Scabia, G., et al. 2021. Brain Behav Immun. 98: 234-244. PMID: 34418501
9. Increase in plasma CCL11 (Eotaxin-1) in patients with alcohol dependence and changes during detoxification.  |  Huang, MC., et al. 2022. Brain Behav Immun. 99: 83-90. PMID: 34571176
10. The role of the eosinophil-selective chemokine, eotaxin, in allergic and non-allergic airways inflammation.  |  Conroy, DM., et al. 1997. Mem Inst Oswaldo Cruz. 92 Suppl 2: 183-91. PMID: 9698931

The preferred MCP-1-4/eotaxin antibody is MCP-1-4/eotaxin Antibody (B-2): sc-377082.