Endophilin I Antibody (G-8): sc-46702
- Endophilin I Antibody (G-8) is a mouse monoclonal IgG2b κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 53-352 of Endophilin I of human origin
- recommended for detection of Endophilin I of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; may cross-react with Endophilin II and Endophilin III
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Endophilin I Antibody (G-8) for WB and IHC(P) applications. These reagents are now offered in bundles with Endophilin I Antibody (G-8) (see ordering information below).
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Endophilin I Antibody (G-8) is a mouse monoclonal IgG2b antibody that detects Endophilin I in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Endophilin I plays a crucial role in the regulation of synaptic vesicle trafficking at nerve terminals, which is essential for proper neurotransmission and communication between neurons. Endophilin I is primarily localized in the brain, highlighting its specific function in neuronal synapses, where Endophilin I interacts with other key proteins such as Amphiphysin, Synaptojanin, and Dynamin. These interactions are vital for the endocytic process, allowing for the recycling of synaptic vesicles and maintaining synaptic function. Additionally, Endophilin I has been shown to modulate G protein-coupled receptor signaling by acting as an adapter protein, directing β1 adrenergic receptors to the endocytic machinery, thereby influencing various signaling pathways that are critical for neuronal health and function. Anti-Endophilin I antibody (G-8) is an invaluable tool for researchers studying synaptic dynamics and the molecular mechanisms underlying neurotransmission.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Endophilin I Antibody (G-8) References:
- Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid. | Schmidt, A., et al. 1999. Nature. 401: 133-41. PMID: 10490020
- Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1. | Howard, L., et al. 1999. J Biol Chem. 274: 31693-9. PMID: 10531379
- Differential expression of endophilin 1 and 2 dimers at central nervous system synapses. | Ringstad, N., et al. 2001. J Biol Chem. 276: 40424-30. PMID: 11518713
- Syndapin I and endophilin I bind overlapping proline-rich regions of dynamin I: role in synaptic vesicle endocytosis. | Anggono, V. and Robinson, PJ. 2007. J Neurochem. 102: 931-43. PMID: 17437541
- Endophilin I expression is increased in the brains of Alzheimer disease patients. | Ren, Y., et al. 2008. J Biol Chem. 283: 5685-91. PMID: 18167351
- Endophilin-1 regulates blood-brain barrier permeability by controlling ZO-1 and occludin expression via the EGFR-ERK1/2 pathway. | Liu, W., et al. 2014. Brain Res. 1573: 17-26. PMID: 24854121
- Endophilin-1 regulates blood-brain barrier permeability via EGFR-JNK signaling pathway. | Chen, L., et al. 2015. Brain Res. 1606: 44-53. PMID: 25721793
- MicroRNA-107 prevents amyloid-beta induced blood-brain barrier disruption and endothelial cell dysfunction by targeting Endophilin-1. | Liu, W., et al. 2016. Exp Cell Res. 343: 248-257. PMID: 27038654
- The role of LINC00094/miR-224-5p (miR-497-5p)/Endophilin-1 axis in Memantine mediated protective effects on blood-brain barrier in AD microenvironment. | Zhu, L., et al. 2019. J Cell Mol Med. 23: 3280-3292. PMID: 30801976
- Endophilin 1 knockdown prevents synaptic dysfunction induced by oligomeric amyloid β. | Yin, Y., et al. 2019. Mol Med Rep. 19: 4897-4905. PMID: 31059028
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Endophilin I Antibody (G-8) | sc-46702 | 200 µg/ml | $316.00 | |||
Endophilin I Antibody (G-8): m-IgG Fc BP-HRP Bundle | sc-536793 | 200 µg Ab; 10 µg BP | $354.00 | |||
Endophilin I Antibody (G-8): m-IgGκ BP-HRP Bundle | sc-533957 | 200 µg Ab; 40 µg BP | $354.00 | |||
Endophilin I Antibody (G-8): m-IgG2b BP-HRP Bundle | sc-549830 | 200 µg Ab; 10 µg BP | $354.00 |