Egr-3 Antibody (A-7): sc-390967

Egr-3 Antibody (A-7) is a mouse monoclonal IgG2b kappa light chain antibody that detects Egr-3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Egr-3 antibody (A-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Egr-3, a member of the early growth response (Egr) family of transcription factors, plays a crucial role in muscle spindle development and is rapidly expressed in T cells shortly after activation, highlighting Egr-3′s importance in immune response regulation. Egr-3 is primarily located in the nucleus, where Egr-3 functions as a transcriptional regulator, influencing the expression of genes involved in cellular growth, differentiation, and survival. This nuclear localization allows Egr-3 to respond swiftly to extracellular signals, thereby modulating gene expression in real-time, which is essential for processes such as muscle development and immune cell activation. Egr-3 monoclonal antibody (A-7) is an invaluable tool for researchers studying these critical biological processes and the underlying mechanisms of transcriptional regulation.

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Egr-3 Antibody (A-7) References:

1. FasL promoter activation by IL-2 through SP1 and NFAT but not Egr-2 and Egr-3.  |  Xiao, S., et al. 1999. Eur J Immunol. 29: 3456-65. PMID: 10556800
2. Chronic ethanol has region-selective effects on Egr-1 and Egr-3 DNA-binding activity and protein expression in the rat brain.  |  Depaz, IM., et al. 2000. Neurochem Int. 37: 473-82. PMID: 10871699
3. Integration of G-protein coupled receptor signaling pathways for activation of a transcription factor (EGR-3).  |  Tan, X., et al. 2003. Genomics Proteomics Bioinformatics. 1: 173-9. PMID: 15629029
4. Egr-2 and Egr-3 are negative regulators of T cell activation.  |  Safford, M., et al. 2005. Nat Immunol. 6: 472-80. PMID: 15834410
5. Early growth response proteins EGR-4 and EGR-3 interact with immune inflammatory mediators NF-kappaB p50 and p65.  |  Wieland, GD., et al. 2005. J Cell Sci. 118: 3203-12. PMID: 16014385
6. Identification of activity-induced Egr3-dependent genes reveals genes associated with DNA damage response and schizophrenia.  |  Marballi, KK., et al. 2022. Transl Psychiatry. 12: 320. PMID: 35941129
7. egr3 is a mechanosensitive transcription factor gene required for cardiac valve morphogenesis.  |  da Silva, AR., et al. 2024. Sci Adv. 10: eadl0633. PMID: 38748804
8. EGR3 Inhibits Tumor Progression by Inducing Schwann Cell-Like Differentiation.  |  Chen, CH., et al. 2024. Adv Sci (Weinh). 11: e2400066. PMID: 38973154
9. Egr transcription factors in the nervous system.  |  Beckmann, AM. and Wilce, PA. 1997. Neurochem Int. 31: 477-510; discussion 517-6. PMID: 9307998
10. The human zinc finger protein EGR-4 acts as autoregulatory transcriptional repressor.  |  Zipfel, PF., et al. 1997. Biochim Biophys Acta. 1354: 134-44. PMID: 9396630
11. Sequential expression of Egr-1 and Egr-3 in hippocampal granule cells following electroconvulsive stimulation.  |  O'Donovan, KJ., et al. 1998. J Neurochem. 70: 1241-8. PMID: 9489747
12. Cyclosporin A-sensitive transcription factor Egr-3 regulates Fas ligand expression.  |  Mittelstadt, PR. and Ashwell, JD. 1998. Mol Cell Biol. 18: 3744-51. PMID: 9632757

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Egr-3 Antibody (A-7) has 12 citations in a variety of scientific publications.

Primary antibodies like Anti-Egr-3 Antibody (A-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Egr-3 Antibody (A-7) Specifications

Alternate Product Name: Egr-3

Product Clone Name: A-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-180

Epitope Target: Egr-3

Epitope Species: human

Product Reactivity/Detection: Egr-3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 12 citations in various scientific publications

Available Conjugates/Forms for Egr-3 Antibody (A-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent