EGFR Antibody (G-3): sc-514994

EGFR Antibody (G-3) is a mouse monoclonal IgG2a antibody that detects amino acids 107-272 mapping near the N-terminus of EGFR of human origin in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). EGFR, or epidermal growth factor receptor, is a critical receptor tyrosine kinase that plays a vital role in cell signaling pathways that regulate cell proliferation, survival, and differentiation. Located primarily on the cell membrane, EGFR is activated upon binding to its ligands, including epidermal growth factor and transforming growth factor alpha, leading to receptor dimerization and subsequent activation of its intrinsic tyrosine kinase activity. This activation triggers a cascade of downstream signaling pathways, such as the RAS-RAF-MAPK and PI3K-AKT pathways, which are essential for normal cellular functions and tissue homeostasis. However, aberrant activation of EGFR is frequently associated with various cancers, as EGFR can promote uncontrolled cell growth, invasion, and metastasis. The presence of EGFR in tumor cells not only serves as a biomarker for cancer diagnosis but also presents a promising therapeutic target, as inhibiting EGFR activity can lead to reduced tumor growth and improved patient outcomes. Anti-EGFR antibody (G-3) is therefore an invaluable tool for researchers studying the role of this receptor in cancer biology and therapeutic interventions.

The preferred EGFR antibody is EGFR Antibody (528): sc-120.