EGFR Antibody (F-2): sc-514995

EGFR Antibody (F-2) is a mouse monoclonal IgG2a antibody that detects epidermal growth factor receptor (EGFR) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). EGFR is a critical receptor tyrosine kinase that plays a pivotal role in cell signaling pathways, particularly those involved in cell growth, survival, and differentiation. EGFR structure is characterized by an extracellular ligand-binding domain, a single transmembrane helix, and an intracellular tyrosine kinase domain, which are essential for function. Proper functioning of EGFR is crucial for normal cellular processes, as EGFR regulates organ morphogenesis and tissue repair. However, aberrations in EGFR, such as mutations or overexpression, can lead to uncontrolled cell proliferation and are frequently associated with various carcinomas, making EGFR a significant target for cancer therapies. EGFR′s ability to form homodimers or heterodimers upon ligand binding further enhances signaling capabilities, contributing to oncogenic potential. By utilizing anti-EGFR antibody (F-2), researchers can effectively study EGFR′s role in cancer progression and explore potential therapeutic interventions targeting this vital protein.

The preferred EGFR antibody is EGFR Antibody (528): sc-120.