EDG-2 Antibody (D-6): sc-515680

EDG-2 Antibody (D-6) is a mouse monoclonal IgG2b kappa light chain antibody that detects EDG-2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). EDG-2 (D-6) antibody is available as a non-conjugated format. EDG-2 protein, also known as LPAR1 or LPA1, is a member of the endothelial differentiation gene (EDG) family of G protein-coupled receptors, which play a crucial role in cellular signaling by binding to lysophospholipid mediators such as lysophosphatidic acid (LPA). EDG-2 protein is primarily located in the brain, particularly in white matter tracts, where EDG-2 is involved in important processes such as cell survival, growth, migration, and differentiation. EDG-2 interaction with LPA activates multiple signaling pathways through various G proteins, including Ras, MAP kinase, and Rho, which are essential for maintaining normal cellular functions and responses to external stimuli. EDG-2 expression in the brain highlights EDG-2′s potential role in neurodevelopment and neuroprotection, making EDG-2 a valuable target for research in neurological disorders. With EDG-2′s ability to facilitate understanding of these critical biological processes, anti-EDG-2 antibody (D-6) serves as an essential tool for researchers investigating the intricate signaling mechanisms mediated by lysophospholipids.

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EDG-2 Antibody (D-6) References:

1. Two novel Xenopus homologs of mammalian LP(A1)/EDG-2 function as lysophosphatidic acid receptors in Xenopus oocytes and mammalian cells.  |  Kimura, Y., et al. 2001. J Biol Chem. 276: 15208-15. PMID: 11278944
2. Neurobiology of the Edg2 lysophosphatidic acid receptor.  |  Yoshida, A. and Ueda, H. 2001. Jpn J Pharmacol. 87: 104-9. PMID: 11700008
3. Lipid phosphate phosphatase-1 and Ca2+ control lysophosphatidate signaling through EDG-2 receptors.  |  . 2003. J Biol Chem. 278: 38104. PMID: 14610755
4. Nm23-H1 suppresses metastasis by inhibiting expression of the lysophosphatidic acid receptor EDG2.  |  Horak, CE., et al. 2007. Cancer Res. 67: 11751-9. PMID: 18089805
5. EDG2 enhanced the progression of hepatocellular carcinoma by LPA/PI3K/AKT/ mTOR signaling.  |  Xu, M., et al. 2017. Oncotarget. 8: 66154-66168. PMID: 29029500
6. NM23 downregulation and lysophosphatidic acid receptor EDG2/lpa1 upregulation during myeloid differentiation of human leukemia cells.  |  Okabe-Kado, J., et al. 2018. Leuk Res. 66: 39-48. PMID: 29407582
7. Interfering with lysophosphatidic acid receptor edg2/lpa1 signalling slows down disease progression in SOD1-G93A transgenic mice.  |  Gento-Caro, Á., et al. 2021. Neuropathol Appl Neurobiol. 47: 1004-1018. PMID: 33508894
8. Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid.  |  An, S., et al. 1997. Biochem Biophys Res Commun. 231: 619-22. PMID: 9070858
9. A single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid.  |  Fukushima, N., et al. 1998. Proc Natl Acad Sci U S A. 95: 6151-6. PMID: 9600933
10. Lysophosphatidic acid receptor gene vzg-1/lpA1/edg-2 is expressed by mature oligodendrocytes during myelination in the postnatal murine brain.  |  Weiner, JA., et al. 1998. J Comp Neurol. 398: 587-98. PMID: 9717712

The preferred EDG-2 antibody is EDG-2 Antibody (B-10): sc-515665.