EDAR Antibody (H-7): sc-271652

EDAR Antibody (H-7) is a mouse monoclonal IgG1 antibody that detects ectodermal dysplasia receptor (EDAR) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). EDAR plays a crucial role in ectodermal differentiation and is integral to signaling pathways that regulate cellular functions such as proliferation and apoptosis. EDAR (H-7) antibody helps study the activation of the NFκB pathway, which promotes cell survival, as well as the caspase and Jun kinase pathways that lead to programmed cell death. EDAR′s importance is underscored by its association with ectodermal dysplasia syndromes, which result from mutations in the downless gene that encodes this receptor, leading to developmental issues in hair, teeth, and sweat glands. The interaction between EDAR and its ligand, Ectodysplasin A (EDA), is vital for proper pathway functioning, as EDA-A1, the longest splice variant of EDA, binds to EDAR to initiate signaling cascades essential for ectodermal development. Post-translational modifications on EDAR can influence stability and activity, further emphasizing EDAR′s importance in cellular signaling and development. Anti-EDAR antibody (H-7) serves as an essential tool for researchers studying the mechanisms of ectodermal differentiation and EDAR′s implications in various developmental disorders.

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EDAR Antibody (H-7) References:

1. Anti-EDAR Agonist Antibody Therapy Resolves Palate Defects in Pax9-/- Mice.  |  Jia, S., et al. 2017. J Dent Res. 96: 1282-1289. PMID: 28813171
2. Modeling Edar expression reveals the hidden dynamics of tooth signaling center patterning.  |  Sadier, A., et al. 2019. PLoS Biol. 17: e3000064. PMID: 30730874
3. Editors' Note to: EDAR, LYPLAL1, PRDM16, PAX3, DKK1, TNFSF12, CACNA2D3, and SUPT3H gene variants influence facial morphology in a Eurasian population.  |  ,. 2020. Hum Genet. 139: 273. PMID: 31807863
4. Ectodysplasin A receptor (EDAR) promotes colorectal cancer cell proliferation via regulation of the Wnt/β-catenin signaling pathway.  |  Wang, B., et al. 2020. Exp Cell Res. 395: 112170. PMID: 32682783
5. Homozygous variants of EDAR underlying hypohidrotic ectodermal dysplasia in three consanguineous families.  |  Khan, SA., et al. 2020. Eur J Dermatol. 30: 408-416. PMID: 32819890
6. Methods for the Administration of EDAR Pathway Modulators in Mice.  |  Schuepbach-Mallepell, S., et al. 2021. Methods Mol Biol. 2248: 167-183. PMID: 33185875
7. The human EDAR 370V/A polymorphism affects tooth root morphology potentially through the modification of a reaction-diffusion system.  |  Kataoka, K., et al. 2021. Sci Rep. 11: 5143. PMID: 33664401
8. miR-29a-5p Inhibits Prenatal Hair Placode Formation Through Targeting EDAR by ceRNA Regulatory Network.  |  Jiang, Y., et al. 2022. Front Cell Dev Biol. 10: 902026. PMID: 35646897
9. EDA ligand triggers plasma membrane trafficking of its receptor EDAR via PKA activation and SNAP23-containing complexes.  |  Yao, Y., et al. 2023. Cell Biosci. 13: 128. PMID: 37430358
10. Depletion of G9A attenuates imiquimod-induced psoriatic dermatitis via targeting EDAR-NF-κB signaling in keratinocyte.  |  Fang, Z., et al. 2023. Cell Death Dis. 14: 627. PMID: 37739945

The preferred EDAR antibody is EDAR Antibody (G-1): sc-271627.