EDAR Inhibitors
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has been shown to downregulate NF-κB signaling, potentially leading to decreased transcriptional activation of target genes, including the EDAR gene, which may result in lower EDAR protein levels. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is known to reduce the activity of Sirtuins and may also decrease NF-κB pathway activity, which could lead to a reduction in EDAR gene expression by altering the transcription machinery. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin, by inhibiting mTOR signaling, could lead to a reduction in protein synthesis and cell proliferation, with a possible consequent decrease in EDAR protein synthesis if EDAR expression is coupled to these cellular states. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY 294002, as a PI3K inhibitor, may lead to the inhibition of the Akt pathway, resulting in reduced phosphorylation and activation of downstream proteins that could be involved in EDAR gene transcription. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine can induce DNA demethylation, which may decrease EDAR expression by altering the methylation status of the gene's promoter region, thereby changing its accessibility to transcription factors. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A, by inhibiting histone deacetylases, could cause hyperacetylation of histones, leading to a less compact chromatin structure and a potential decrease in EDAR gene transcription due to altered gene accessibility. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid may decrease EDAR expression by binding to retinoic acid receptors, which can alter the expression of genes involved in cell differentiation and proliferation that are potentially linked to EDAR gene expression. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $94.00 $208.00 | 19 | |
Cyclopamine directly inhibits Smoothened, a component of the Hedgehog signaling pathway, which could lead to decreased expression of downstream target genes, potentially including EDAR. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib may decrease EDAR expression indirectly by inhibiting the proteasome, leading to an accumulation of misfolded proteins and a cellular stress response that could alter gene expression patterns. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $111.00 $357.00 | 8 | |
Thalidomide has been observed to downregulate several cytokines and growth factors, which could result in reduced expression of EDAR if these cytokines are upstream regulators of the EDAR gene. | ||||||