dystrophin Antibody (3B7): sc-33698
- dystrophin Antibody (3B7) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against recombinant fragment of human dystrophin
- recommended for detection of dystrophin of mouse, rat and human origin by WB, IP and IF
- See dystrophin (MANDRA1): sc-73592 for dystrophin antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for dystrophin Antibody (3B7) for WB applications. These reagents are now offered in bundles with dystrophin Antibody (3B7) (see ordering information below).
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Dystrophin Antibody (3B7) is a mouse monoclonal IgG2a antibody that detects dystrophin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Dystrophin plays a crucial role in maintaining the structural integrity of muscle fibers by linking the F-Actin cytoskeleton to the extracellular matrix at the cell membrane interface, forming the dystrophin-glycoprotein complex (DGC). This connection is vital for muscle function, as dystrophin helps to stabilize the muscle cell membrane during contraction and protects against injury. A deficiency in dystrophin is associated with severe muscle disorders, including Duchenne and Becker muscular dystrophies, highlighting dystrophin′s importance in muscle health. The human dystrophin gene is notably large, spanning 2.4 megabases with over 80 exons, and produces a 14 kb mRNA that can undergo differential splicing to generate various transcripts, each encoding different protein isoforms. Dystrophin is localized to triadic junctions in skeletal muscle, where dystrophin plays a significant role in calcium ion homeostasis and force transmission, making dystrophin essential for effective muscle contraction and overall muscle function. Anti-dystrophin antibody (3B7) serves as an invaluable tool for researchers studying muscular dystrophies and muscle biology, providing insights into the molecular mechanisms underlying these conditions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
dystrophin Antibody (3B7) References:
- The dystrophin-associated protein complex. | Ehmsen, J., et al. 2002. J Cell Sci. 115: 2801-3. PMID: 12082140
- Dystrophin complex functions as a scaffold for signalling proteins. | Constantin, B. 2014. Biochim Biophys Acta. 1838: 635-42. PMID: 24021238
- Proteomics of the dystrophin-glycoprotein complex and dystrophinopathy. | Holland, A., et al. 2013. Curr Protein Pept Sci. 14: 680-97. PMID: 24106963
- Dystrophin-glycoprotein complex sequesters Yap to inhibit cardiomyocyte proliferation. | Morikawa, Y., et al. 2017. Nature. 547: 227-231. PMID: 28581498
- Dynamics of Dystrophin's Actin-Binding Domain. | Fealey, ME., et al. 2018. Biophys J. 115: 445-454. PMID: 30007583
- Dystrophin As a Molecular Shock Absorber. | Le, S., et al. 2018. ACS Nano. 12: 12140-12148. PMID: 30457830
- Dystrophin involvement in peripheral circadian SRF signalling. | Betts, CA., et al. 2021. Life Sci Alliance. 4: PMID: 34389686
- The importance of dystrophin and the dystrophin associated proteins in vascular smooth muscle. | Kaplan, KM. and Morgan, KG. 2022. Front Physiol. 13: 1059021. PMID: 36505053
- Decreased dystrophin expression and elevated dystrophin-targeting miRNAs in anti-HMGCR immune-mediated necrotizing myopathy. | Marmen, MB., et al. 2023. Acta Neuropathol. 146: 655-658. PMID: 37543531
- Juvenile cardiomyopathy with dystrophin deficiency. | Luo, Y., et al. 2024. Genes Dis. 11: 100980. PMID: 38274373
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
dystrophin Antibody (3B7) | sc-33698 | 200 µg/ml | $322.00 | |||
dystrophin Antibody (3B7): m-IgG Fc BP-HRP Bundle | sc-536780 | 200 µg Ab; 10 µg BP | $361.00 | |||
dystrophin Antibody (3B7): m-IgGκ BP-HRP Bundle | sc-533944 | 200 µg Ab; 40 µg BP | $361.00 | |||
dystrophin Antibody (3B7): m-IgG2a BP-HRP Bundle | sc-547869 | 200 µg Ab; 10 µg BP | $361.00 |