dystrophin Inhibitors

Common dystrophin Inhibitors include, but are not limited to Doxorubicin CAS 23214-92-8, Isoproterenol Hydrochloride CAS 51-30-9, Cisplatin CAS 15663-27-1, Cyclosporin A CAS 59865-13-3 and Colchicine CAS 64-86-8.

Dystrophin is a large, rod-shaped cytoplasmic protein that plays a pivotal role in maintaining the structural integrity of muscle cells. Located on the inner surface of muscle fibers, dystrophin is crucial for connecting the cytoskeleton of a muscle fiber to the surrounding extracellular matrix through a protein complex. This structural connection is vital for the distribution and dissipation of the mechanical force across the muscle during muscle contraction. A deficiency or dysfunction of dystrophin can lead to muscle weakness and degeneration.

Dystrophin inhibitors are molecules designed to modulate the function or expression of dystrophin. These compounds can act by directly interfering with dystrophin's protein structure or by affecting the cellular pathways that regulate its synthesis and degradation. Understanding the biological outcomes of dystrophin inhibition can provide insights into the protein's intricate role in muscle biology. Researchers can utilize these inhibitors to study dystrophin's interactions with other proteins in the muscle cell membrane, the consequences of its reduced function or absence, and the cellular mechanisms that regulate its expression.