dsg2 Antibody (F-8): sc-365856

dsg2 Antibody (F-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects Desmoglein 2 (dsg2) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). dsg2 Antibody (F-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Desmoglein 2 (dsg2) plays a crucial role in maintaining cell adhesion, particularly in desmosomes, which are specialized structures that provide mechanical strength to tissues. dsg2 is essential for epithelial tissue integrity, and dysfunction can lead to various skin disorders, including pemphigus, an autoimmune condition characterized by blistering due to autoantibodies against desmogleins. dsg2 (F-8) antibody targets the largest member of the desmoglein family, expressed in all desmosome-containing tissues, highlighting a fundamental role in cellular adhesion. Abnormal dsg2 levels have been associated with tumor progression and metastasis, suggesting potential use as a biomarker for certain malignancies. anti-dsg2 antibody (F-8) effectively detects across multiple species and applications, making dsg2 (F-8) monoclonal antibody an invaluable tool for researchers studying cell adhesion mechanisms and related pathologies.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

dsg2 Antibody (F-8) References:

1. c-Src/Cav1-dependent activation of the EGFR by Dsg2.  |  Overmiller, AM., et al. 2016. Oncotarget. 7: 37536-37555. PMID: 26918609
2. Dsg2 via Src-mediated transactivation shapes EGFR signaling towards cell adhesion.  |  Ungewiß, H., et al. 2018. Cell Mol Life Sci. 75: 4251-4268. PMID: 29980799
3. In vitro analysis of arrhythmogenic cardiomyopathy associated desmoglein-2 (DSG2) mutations reveals diverse glycosylation patterns.  |  Debus, JD., et al. 2019. J Mol Cell Cardiol. 129: 303-313. PMID: 30885746
4. Desmoglein 2 (DSG2) Is A Receptor of Human Adenovirus Type 55 Causing Adult Severe Community-Acquired Pneumonia.  |  Zhang, J., et al. 2021. Virol Sin. 36: 1400-1410. PMID: 34224109
5. TROP2 Down-regulated DSG2 to Promote Gastric Cancer Cell Invasion and Migration by EGFR/AKT and DSG2/PG/β-Catenin Pathways.  |  Yang, T., et al. 2022. Curr Cancer Drug Targets. 22: 691-702. PMID: 35392784
6. Serum DSG2 as a potential biomarker for diagnosis of esophageal squamous cell carcinoma and esophagogastric junction adenocarcinoma.  |  Liu, YQ., et al. 2022. Biosci Rep. 42: PMID: 35521959
7. Up-regulation of Dsg2 confered stem cells with malignancy through wnt/β-catenin signaling pathway.  |  Chen, L., et al. 2023. Exp Cell Res. 422: 113416. PMID: 36375513
8. Reactivation of PPARα alleviates myocardial lipid accumulation and cardiac dysfunction by improving fatty acid β-oxidation in Dsg2-deficient arrhythmogenic cardiomyopathy.  |  Lin, Y., et al. 2023. Acta Pharm Sin B. 13: 192-203. PMID: 36815030
9. Ser194Leu DSG2 mutation, associated with arrhythmogenic left ventricular cardiomyopathy and ventricular tachycardia.  |  Blich, M., et al. 2024. Pacing Clin Electrophysiol. 47: 503-510. PMID: 38375917
10. Dsg2 ectodomain organization increases throughout desmosome assembly.  |  Dean, WF., et al. 2024. Cell Adh Migr. 18: 1-13. PMID: 38566311

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-dsg2 Antibody (F-8) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-dsg2 Antibody (F-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

dsg2 Antibody (F-8) Specifications

Alternate Product Name: dsg2

Product Clone Name: F-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 816-960

Epitope Target: dsg2

Epitope Species: human

Product Reactivity/Detection: dsg2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for dsg2 Antibody (F-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred dsg2 antibody is dsg2 Antibody (AH12.2): sc-80663.