dsg2 Antibody (F-5): sc-390531

dsg2 Antibody (F-5) is a mouse monoclonal IgG1 antibody that detects desmoglein 2 (dsg2) in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). dsg2 plays a crucial role in maintaining cell adhesion, particularly in desmosomes, which are specialized structures that provide mechanical strength to tissues by anchoring adjacent cells together. This function is vital for the integrity of epithelial tissues, and any disruption in dsg2 expression can lead to severe consequences, including the development of autoimmune diseases like pemphigus. dsg2 is the largest member of the desmoglein family and is expressed in all desmosome-containing tissues, highlighting its fundamental role in cellular architecture. dsg2 expression is particularly significant in cancer, as abnormal levels have been linked to tumor progression and metastasis, making dsg2 a potential biomarker for cancer diagnostics and a target for therapeutic interventions. anti-dsg2 antibody (F-5) is an essential tool for researchers investigating the molecular mechanisms underlying cell adhesion and the pathogenesis of related diseases.

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dsg2 Antibody (F-5) References:

1. DSG2 mutations contribute to arrhythmogenic right ventricular dysplasia/cardiomyopathy.  |  Awad, MM., et al. 2006. Am J Hum Genet. 79: 136-42. PMID: 16773573
2. Suprabasal Dsg2 expression in transgenic mouse skin confers a hyperproliferative and apoptosis-resistant phenotype to keratinocytes.  |  Brennan, D., et al. 2007. J Cell Sci. 120: 758-71. PMID: 17284515
3. Myocyte necrosis underlies progressive myocardial dystrophy in mouse dsg2-related arrhythmogenic right ventricular cardiomyopathy.  |  Pilichou, K., et al. 2009. J Exp Med. 206: 1787-802. PMID: 19635863
4. Enhancement of Cutaneous Wound Healing by Dsg2 Augmentation of uPAR Secretion.  |  Cooper, F., et al. 2018. J Invest Dermatol. 138: 2470-2479. PMID: 29753032
5. DSG2 Is a Functional Cell Surface Marker for Identification and Isolation of Human Pluripotent Stem Cells.  |  Park, J., et al. 2018. Stem Cell Reports. 11: 115-127. PMID: 29910125
6. Distal myopathy induced arrhythmogenic right ventricular cardiomyopathy in a pedigree carrying novel DSG2 null variant.  |  Chen, P., et al. 2020. Int J Cardiol. 298: 25-31. PMID: 31653443
7. Negative Expression of DSG1 and DSG2, as Prognostic Biomarkers, Impacts on the Overall Survival in Patients with Extrahepatic Cholangiocarcinoma.  |  Xu, S., et al. 2020. Anal Cell Pathol (Amst). 2020: 9831646. PMID: 32850288
8. Properties of Adenovirus Vectors with Increased Affinity to DSG2 and the Potential Benefits of Oncolytic Approaches and Gene Therapy.  |  Bahlmann, NA., et al. 2022. Viruses. 14: PMID: 36016457
9. DSG2 and c-MYC Interact to Regulate the Expression of ADAM17 and Promote the Development of Cervical Cancer.  |  Song, LM., et al. 2024. Cancer Manag Res. 16: 703-710. PMID: 38948682
10. Prevalence and Correlates of Anti-DSG2 Antibodies in Arrhythmogenic Right Ventricular Cardiomyopathy and Myocarditis: Immunological Insights from a Multicenter Study.  |  Giordani, AS., et al. 2024. J Clin Med. 13: PMID: 39597880

The preferred dsg2 antibody is dsg2 Antibody (AH12.2): sc-80663.