dsg2 Antibody (6D8): sc-53486
- dsg2 Antibody (6D8) is a mouse monoclonal IgG1 κ, cited in 7 publications, provided at 200 µg/ml
- raised against A-431 cell shavings
- recommended for detection of dsg2 of human origin by WB, IP and IF; non cross-reactive with Desmoglein 1 or 3
- See dsg2 (AH12.2): sc-80663 for dsg2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for dsg2 Antibody (6D8) for WB applications. These reagents are now offered in bundles with dsg2 Antibody (6D8) (see ordering information below).
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dsg2 Antibody (6D8) is a mouse monoclonal IgG1 antibody that detects desmoglein 2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). anti-desmoglein 2 antibody (6D8) plays a crucial role in studying desmoglein 2, a type I membrane protein that is essential for maintaining cell adhesion within desmosomes, which are specialized structures that provide mechanical strength to tissues. desmoglein 2 (6D8) monoclonal antibody enables research of this protein, predominantly located in the plasma membrane of epithelial cells, where desmoglein 2 forms adhesive junctions with neighboring cells, thereby contributing to the integrity of tissues under mechanical stress. The proper functioning of desmoglein 2 is vital for skin health, as dysfunction can lead to various skin disorders, including pemphigus vulgaris, an autoimmune condition characterized by blistering and loss of cell adhesion. desmoglein 2 (6D8) antibody supports research into how desmoglein 2 interacts with other proteins in the cadherin family, which are critical for cell-cell adhesion and signaling pathways. Understanding the expression and function of desmoglein 2 can provide insights into the mechanisms underlying skin diseases and potential therapeutic targets for treatment.
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dsg2 Antibody (6D8) References:
- In vitro analysis of arrhythmogenic cardiomyopathy associated desmoglein-2 (DSG2) mutations reveals diverse glycosylation patterns. | Debus, JD., et al. 2019. J Mol Cell Cardiol. 129: 303-313. PMID: 30885746
- Stabilization of desmoglein-2 binding rescues arrhythmia in arrhythmogenic cardiomyopathy. | Schinner, C., et al. 2020. JCI Insight. 5: PMID: 32376797
- Desmoglein 2 (DSG2) Is A Receptor of Human Adenovirus Type 55 Causing Adult Severe Community-Acquired Pneumonia. | Zhang, J., et al. 2021. Virol Sin. 36: 1400-1410. PMID: 34224109
- Autoantibodies against desmoglein 2 are not pathogenic in pemphigus. | Miguel, MCB., et al. 2022. An Bras Dermatol. 97: 145-156. PMID: 35058080
- The prognostic and clinicopathological significance of desmoglein 2 in human cancers: a systematic review and meta-analysis. | Wang, J., et al. 2022. PeerJ. 10: e13141. PMID: 35345582
- Desmoglein-2 is important for islet function and β-cell survival. | Myo Min, KK., et al. 2022. Cell Death Dis. 13: 911. PMID: 36309486
- SARS-CoV-2 infection is associated with anti-desmoglein 2 autoantibody detection. | Ward, KE., et al. 2023. Clin Exp Immunol. 213: 243-251. PMID: 37095599
- Molecular insight into arrhythmogenic cardiomyopathy caused by DSG2 mutations. | Zhang, B., et al. 2023. Biomed Pharmacother. 167: 115448. PMID: 37696084
- The role of desmoglein-2 in kidney disease. | Xu, T., et al. 2024. Kidney Int. 105: 1035-1048. PMID: 38395410
- Serine/threonine-protein kinase D2-mediated phosphorylation of DSG2 threonine 730 promotes esophageal squamous cell carcinoma progression. | Liu, YQ., et al. 2024. J Pathol. 263: 99-112. PMID: 38411280
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
dsg2 Antibody (6D8) | sc-53486 | 200 µg/ml | $322.00 | |||
dsg2 Antibody (6D8): m-IgG Fc BP-HRP Bundle | sc-538993 | 200 µg Ab; 10 µg BP | $361.00 | |||
dsg2 Antibody (6D8): m-IgG1 BP-HRP Bundle | sc-541196 | 200 µg Ab; 20 µg BP | $361.00 |