DR3 Antibody (D3 2-1-1): sc-53974
- DR3 Antibody (D3 2-1-1) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against recombinant full length DR3 of human origin
- recommended for detection of DR3 of human origin by WB, IP, FCM and ELISA
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for DR3 Antibody (D3 2-1-1) for WB applications. These reagents are now offered in bundles with DR3 Antibody (D3 2-1-1) (see ordering information below).
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DR3 Antibody (D3 2-1-1) is a mouse monoclonal IgG1 antibody that detects DR3 in human samples through applications such as western blotting (WB), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). DR3, also known as Wsl-1, APO-3, TRAMP, and LARD, is a member of the tumor necrosis factor (TNF) receptor superfamily and plays a crucial role in mediating apoptosis and activating the NFκB signaling pathway. DR3 is primarily expressed in thymocytes and lymphocytes, highlighting its importance in immune regulation and response. DR3′s presence in these immune cells suggests involvement in T-cell development and function, making DR3 a significant target for research in immunology and potential therapeutic interventions. The unique structure of DR3, characterized by its death domain, allows interaction with various intracellular signaling molecules, further emphasizing DR3′s role in apoptosis and cellular homeostasis. Anti-DR3 antibody (D3 2-1-1) is an essential tool for researchers investigating the complex mechanisms of immune responses and cell death.
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DR3 Antibody (D3 2-1-1) References:
- TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator. | Migone, TS., et al. 2002. Immunity. 16: 479-92. PMID: 11911831
- The TL1A/DR3/DcR3 pathway in autoimmune rheumatic diseases. | Siakavellas, SI., et al. 2015. Semin Arthritis Rheum. 45: 1-8. PMID: 25887448
- Activation of DR3 signaling causes loss of ILC3s and exacerbates intestinal inflammation. | Li, J., et al. 2019. Nat Commun. 10: 3371. PMID: 31358760
- Direct signaling of TL1A-DR3 on fibroblasts induces intestinal fibrosis in vivo. | Jacob, N., et al. 2020. Sci Rep. 10: 18189. PMID: 33097818
- TL1A/DR3 Axis, A Key Target of TNF-a, Augments the Epithelial-Mesenchymal Transformation of Epithelial Cells in OVA-Induced Asthma. | Zhang, D., et al. 2022. Front Immunol. 13: 854995. PMID: 35359966
- DR3 Regulates Intestinal Epithelial Homeostasis and Regeneration After Intestinal Barrier Injury. | Shimodaira, Y., et al. 2023. Cell Mol Gastroenterol Hepatol. 16: 83-105. PMID: 37011811
- The ever-expanding role of cytokine receptor DR3 in T cells. | Liman, N., et al. 2024. Cytokine. 176: 156540. PMID: 38359559
- TL1A/DR3 signaling regulates the generation of pathogenic Th9 cells in experimental inflammatory bowel disease. | Menghini, P., et al. 2024. bioRxiv.. PMID: 38405912
- Quinic acid alleviates high-fat diet-induced neuroinflammation by inhibiting DR3/IKK/NF-κB signaling via gut microbial tryptophan metabolites. | Li, S., et al. 2024. Gut Microbes. 16: 2374608. PMID: 38972055
- Paeoniflorin ameliorates chronic colitis via the DR3 signaling pathway in group 3 innate lymphoid cells. | Huang, S., et al. 2024. J Pharm Anal. 14: 100940. PMID: 39027912
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DR3 Antibody (D3 2-1-1) | sc-53974 | 200 µg/ml | $322.00 | |||
DR3 Antibody (D3 2-1-1): m-IgG Fc BP-HRP Bundle | sc-539017 | 200 µg Ab; 10 µg BP | $361.00 | |||
DR3 Antibody (D3 2-1-1): m-IgG1 BP-HRP Bundle | sc-541210 | 200 µg Ab; 20 µg BP | $361.00 | |||
DR3 Antibody (D3 2-1-1) FITC | sc-53974 FITC | 200 µg/ml | $336.00 | |||
DR3 Antibody (D3 2-1-1) PE | sc-53974 PE | 200 µg/ml | $349.00 |