DR3 Antibody (B-8): sc-374203

DR3 Antibody (B-8) is a mouse monoclonal IgG2b kappa light chain antibody that detects DR3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-DR3 antibody (B-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. DR3, also known as TNFRSF25, plays a crucial role in the immune system by mediating apoptosis and activating the NFκB signaling pathway, which is essential for regulating immune responses and maintaining homeostasis. Located primarily in thymocytes and lymphocytes, DR3 is a member of the tumor necrosis factor receptor superfamily and is characterized by its unique death domain that triggers apoptotic signaling. This specific localization is vital as DR3 effectively participates in the development and activation of T cells, thereby influencing adaptive immunity. DR3′s ability to induce apoptosis in certain immune cells highlights its importance in preventing autoimmune responses and maintaining immune tolerance. With versatile applications and critical role in immune regulation, DR3 (B-8) monoclonal antibody serves as an invaluable tool for researchers studying immune system dynamics and related pathologies.

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DR3 Antibody (B-8) References:

1. The role of TL1A and DR3 in autoimmune and inflammatory diseases.  |  Aiba, Y. and Nakamura, M. 2013. Mediators Inflamm. 2013: 258164. PMID: 24453414
2. HLA-DR3 antigen in the resistance to idiopathic dilated cardiomyopathy.  |  Jin, B., et al. 2016. Braz J Med Biol Res. 49: e5131. PMID: 27007655
3. The TL1A-DR3 Axis in Asthma: Membrane-Bound and Secreted TL1A Co-Determined the Development of Airway Remodeling.  |  Zhang, J., et al. 2022. Allergy Asthma Immunol Res. 14: 233-253. PMID: 35255540
4. The Fas death factor.  |  Nagata, S. and Golstein, P. 1995. Science. 267: 1449-56. PMID: 7533326
5. The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death.  |  Smith, CA., et al. 1994. Cell. 76: 959-62. PMID: 8137429
6. A novel domain within the 55 kd TNF receptor signals cell death.  |  Tartaglia, LA., et al. 1993. Cell. 74: 845-53. PMID: 8397073
7. Apoptosis mediated by the TNF-related cytokine and receptor families.  |  Ware, CF., et al. 1996. J Cell Biochem. 60: 47-55. PMID: 8825415
8. Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95.  |  Chinnaiyan, AM., et al. 1996. Science. 274: 990-2. PMID: 8875942
9. A death-domain-containing receptor that mediates apoptosis.  |  Kitson, J., et al. 1996. Nature. 384: 372-5. PMID: 8934525
10. Apo-3, a new member of the tumor necrosis factor receptor family, contains a death domain and activates apoptosis and NF-kappa B.  |  Marsters, SA., et al. 1996. Curr Biol. 6: 1669-76. PMID: 8994832
11. TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95).  |  Bodmer, JL., et al. 1997. Immunity. 6: 79-88. PMID: 9052839
12. A new death receptor 3 isoform: expression in human lymphoid cell lines and non-Hodgkin's lymphomas.  |  Warzocha, K., et al. 1998. Biochem Biophys Res Commun. 242: 376-9. PMID: 9446802

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-DR3 Antibody (B-8) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-DR3 Antibody (B-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

DR3 Antibody (B-8) Specifications

Alternate Product Name: DR3

Product Clone Name: B-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 387-416

Epitope Target: DR3

Epitope Species: human

Product Reactivity/Detection: DR3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for DR3 Antibody (B-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin