DPP10 Antibody (B-3): sc-398108

DPP10 Antibody (B-3) is a mouse monoclonal IgG1 antibody that detects DPP10 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DPP10, also known as DPRP3 (dipeptidyl peptidase IV-related protein 3), DPL2, or DPPY, is a non-functional dipeptidyl peptidase that plays a crucial role in modulating the activity and surface expression of voltage-gated potassium channels, specifically KV4.1 and KV4.2. This single-pass type II membrane protein is predominantly expressed in the spinal cord, adrenal glands, pancreas, and brain tissues, highlighting DPP10′s importance in the central nervous system and endocrine functions. By interacting with these potassium channels, DPP10 can influence neuronal excitability and synaptic transmission, which are vital for proper neurological function. DPP10′s ability to bind to KV4 channels suggests a role as a regulatory factor in various physiological processes, including cardiac rhythm and neuronal signaling, making DPP10 a significant target for research in understanding diseases related to these systems.

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DPP10 Antibody (B-3) References:

1. Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10).  |  Jerng, HH., et al. 2004. Biophys J. 87: 2380-96. PMID: 15454437
2. DPP10 is an inactivation modulatory protein of Kv4.3 and Kv1.4.  |  Li, HL., et al. 2006. Am J Physiol Cell Physiol. 291: C966-76. PMID: 16738002
3. DPP10 splice variants are localized in distinct neuronal populations and act to differentially regulate the inactivation properties of Kv4-based ion channels.  |  Jerng, HH., et al. 2007. Mol Cell Neurosci. 35: 604-24. PMID: 17475505
4. Impaired glycosylation blocks DPP10 cell surface expression and alters the electrophysiology of Ito channel complex.  |  Cotella, D., et al. 2010. Pflugers Arch. 460: 87-97. PMID: 20354865
5. N-glycosylation of the mammalian dipeptidyl aminopeptidase-like protein 10 (DPP10) regulates trafficking and interaction with Kv4 channels.  |  Cotella, D., et al. 2012. Int J Biochem Cell Biol. 44: 876-85. PMID: 22387313
6. Immunohistochemical localization of DPP10 in rat brain supports the existence of a Kv4/KChIP/DPPL ternary complex in neurons.  |  Wang, WC., et al. 2015. J Comp Neurol. 523: 608-28. PMID: 25355692
7. Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal DPP10-Pulmonary Function Association.  |  Xu, J., et al. 2019. Am J Respir Crit Care Med. 199: 631-642. PMID: 30199657
8. Tetramethylpyrazine reduces prostate cancer malignancy through inactivation of the DPP10‑AS1/CBP/FOXM1 signaling pathway.  |  Zhou, Y., et al. 2020. Int J Oncol. 57: 314-324. PMID: 32319592
9. A novel DPP10 (intergenic)-NTRK3 fusion in a patient with facial malignant melanoma and potentially benefit from NTRK inhibitors.  |  Wei, D., et al. 2021. Oral Oncol. 120: 105288. PMID: 33846089
10. LncRNA DPP10-AS1 promotes malignant processes through epigenetically activating its cognate gene DPP10 and predicts poor prognosis in lung cancer patients.  |  Tian, H., et al. 2021. Cancer Biol Med. 18: 675-92. PMID: 34106559

The preferred DPP10 antibody is DPP10 Antibody (C-1): sc-393442.