DOCK 7 Antibody (A-6): sc-398958

DOCK 7 Antibody (A-6) is a mouse monoclonal IgG1 antibody that detects DOCK 7 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DOCK 7, also known as ZIR2, is a 2,140 amino acid protein that plays a crucial role in the development of the nervous system by localizing to developing axons. DOCK 7 functions as a guanine nucleotide exchange factor (GEF), specifically activating Rac 1 and Rac 3 by facilitating the exchange of bound GDP for free GTP, which is essential for regulating cytoskeletal dynamics and cell migration. Multiple isoforms of DOCK 7, resulting from alternative splicing, add complexity to functional roles in various cellular processes. The gene encoding DOCK 7 is located on human chromosome 1, a region spanning 260 million base pairs and containing over 3,000 genes, housing numerous disease-associated genes linked to conditions such as familial adenomatous polyposis, Parkinson′s disease, and various cancers. Aberrations in chromosome 1 are frequently observed in malignancies, including head and neck cancer and malignant melanoma, highlighting DOCK 7′s importance in both normal physiology and disease states.

The preferred DOCK 7 antibody is DOCK 7 Antibody (C-7): sc-398888.