Dnmt3b Antibody (2280C3a): sc-81252
- Dnmt3b Antibody (2280C3a) is a mouse monoclonal IgG2b, cited in 18 publications, provided at 100 µg/ml
- raised against a recombinant protein corresponding to an internal region of Dnmt3b of human origin
- recommended for detection of Dnmt3b of mouse, rat and human origin by WB, IP and FCM
- See Dnmt3b (G-9): sc-376043 for Dnmt3b antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Dnmt3b Antibody (2280C3a) for WB applications. These reagents are now offered in bundles with Dnmt3b Antibody (2280C3a) (see ordering information below).
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Dnmt3b Antibody (2280C3a) is a mouse monoclonal IgG2b kappa light chain antibody that detects Dnmt3b in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). Anti-Dnmt3b antibody (2280C3a) is available in a non-conjugated form, allowing for versatile experimental use. Dnmt3b plays a crucial role in the regulation of gene expression through DNA methylation, a process vital for normal development and cellular differentiation. Specifically, Dnmt3b is responsible for de novo methylation, which establishes new methylation patterns on previously unmethylated DNA, particularly in embryonic stem cells. This function is essential for silencing genes that should not be expressed in certain cell types, thereby maintaining cellular identity and function. The ability of Dnmt3b to add methyl groups to cytosines within CpG dinucleotides is critical for proper regulation of gene expression, and dysregulation of this process can lead to various diseases, including cancer. Dnmt3b monoclonal antibody (2280C3a) enables researchers to gain insights into the mechanisms of epigenetic regulation and its implications in developmental biology and disease.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Dnmt3b Antibody (2280C3a) References:
- DNMT3B Functions: Novel Insights From Human Disease. | Gagliardi, M., et al. 2018. Front Cell Dev Biol. 6: 140. PMID: 30406101
- Dnmt3b ablation impairs fracture repair through upregulation of Notch pathway. | Ying, J., et al. 2020. JCI Insight. 5: PMID: 32051335
- Dnmt3b Deficiency in Myf5+-Brown Fat Precursor Cells Promotes Obesity in Female Mice. | Wang, S., et al. 2021. Biomolecules. 11: PMID: 34439754
- DNMT3B regulates proliferation of A549 cells through the microRNA-152-3p/NCAM1 pathway. | Yang, B., et al. 2022. Oncol Lett. 23: 11. PMID: 34820010
- DNMT3b protects centromere integrity by restricting R-loop-mediated DNA damage. | Shih, HT., et al. 2022. Cell Death Dis. 13: 546. PMID: 35688824
- DNMT3B supports meso-endoderm differentiation from mouse embryonic stem cells. | Lauria, A., et al. 2023. Nat Commun. 14: 367. PMID: 36690616
- DNMT3B activates FGFR3-mediated endoplasmic reticulum stress by regulating PTPN2 promoter methylation to promote the development of atherosclerosis. | Zhang, Z., et al. 2023. FASEB J. 37: e23085. PMID: 37462502
- DNMT3B Alleviates Liver Steatosis Induced by Chronic Low-grade LPS via Inhibiting CIDEA Expression. | Li, Q., et al. 2024. Cell Mol Gastroenterol Hepatol. 17: 59-77. PMID: 37703946
- Non-coding RNAs/DNMT3B axis in human cancers: from pathogenesis to clinical significance. | Huang, C., et al. 2023. J Transl Med. 21: 621. PMID: 37705098
- Dnmt3b ablation affects fracture repair process by regulating apoptosis. | Wang, X., et al. 2024. BMC Musculoskelet Disord. 25: 180. PMID: 38413962
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dnmt3b Antibody (2280C3a) | sc-81252 | 100 µg/ml | $333.00 | |||
Dnmt3b Antibody (2280C3a): m-IgGκ BP-HRP Bundle | sc-534464 | 100 µg Ab; 40 µg BP | $354.00 | |||
Dnmt3b Antibody (2280C3a): m-IgG2b BP-HRP Bundle | sc-549260 | 100 µg Ab; 10 µg BP | $354.00 |