DNA pol δ cat Antibody (C-2): sc-17777
- DNA pol δ cat Antibody (C-2) is a mouse monoclonal IgG2b κ, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 1-300 of DNA pol δ cat of human origin
- recommended for detection of DNA pol δ cat of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for DNA pol δ cat Antibody (C-2) for WB applications. These reagents are now offered in bundles with DNA pol δ cat Antibody (C-2) (see ordering information below).
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DNA pol δ cat Antibody (C-2) is a mouse monoclonal IgG2b antibody that detects DNA polymerase delta (DNA pol δ) in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-DNA pol δ antibody (C-2) recognizes the enzyme′s crucial role in DNA replication, particularly in processing Okazaki fragments on the lagging strand, which maintains genome stability. DNA pol δ consists of multiple subunits, including p125 that interacts with sliding DNA clamp protein PCNA, and p50, which together enable high-fidelity DNA synthesis. DNA pol δ (C-2) monoclonal antibody helps researchers understand how cell cycle proteins regulate this enzyme, as dysregulation can lead to genomic instability and diseases, including cancer. DNA pol δ (C-2) antibody serves as an essential tool for studying DNA replication and repair mechanisms, offering insights into processes that protect genetic integrity.
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DNA pol δ cat Antibody (C-2) References:
- POLE and POLD1 mutations in 529 kindred with familial colorectal cancer and/or polyposis: review of reported cases and recommendations for genetic testing and surveillance. | Bellido, F., et al. 2016. Genet Med. 18: 325-32. PMID: 26133394
- POLD1: Central mediator of DNA replication and repair, and implication in cancer and other pathologies. | Nicolas, E., et al. 2016. Gene. 590: 128-41. PMID: 27320729
- Evaluation of POLE and POLD1 Mutations as Biomarkers for Immunotherapy Outcomes Across Multiple Cancer Types. | Wang, F., et al. 2019. JAMA Oncol. 5: 1504-1506. PMID: 31415061
- POLE, POLD1, and NTHL1: the last but not the least hereditary cancer-predisposing genes. | Magrin, L., et al. 2021. Oncogene. 40: 5893-5901. PMID: 34363023
- A Comprehensive Prognostic Analysis of POLD1 in Hepatocellular Carcinoma. | Tang, H., et al. 2022. BMC Cancer. 22: 197. PMID: 35189839
- IGF-1 Accelerates Cell Aging by Inhibiting POLD1 Expression. | Hou, YL., et al. 2022. Biomed Environ Sci. 35: 981-991. PMID: 36443251
- Prospects of POLD1 in Human Cancers: A Review. | Gola, M., et al. 2023. Cancers (Basel). 15: PMID: 36980791
- Recommendations for the classification of germline variants in the exonuclease domain of POLE and POLD1. | Mur, P., et al. 2023. Genome Med. 15: 85. PMID: 37848928
- Race, Prevalence of POLE and POLD1 Alterations, and Survival Among Patients With Endometrial Cancer. | Zheng, S., et al. 2024. JAMA Netw Open. 7: e2351906. PMID: 38231514
- Immune checkpoint inhibitors for POLE or POLD1 proofreading-deficient metastatic colorectal cancer. | Ambrosini, M., et al. 2024. Ann Oncol. 35: 643-655. PMID: 38777726
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DNA pol δ cat Antibody (C-2) | sc-17777 | 200 µg/ml | $322.00 | |||
DNA pol δ cat Antibody (C-2): m-IgG Fc BP-HRP Bundle | sc-536587 | 200 µg Ab; 10 µg BP | $361.00 | |||
DNA pol δ cat Antibody (C-2): m-IgGκ BP-HRP Bundle | sc-533738 | 200 µg Ab; 40 µg BP | $361.00 | |||
DNA pol δ cat Antibody (C-2): m-IgG2b BP-HRP Bundle | sc-549814 | 200 µg Ab; 10 µg BP | $361.00 |