Date published: 2025-10-7

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DNA pol ι Antibodies

Santa Cruz Biotechnology provides a broad selection of DNA pol ι Antibodies for investigating the role of this crucial enzyme in DNA replication and repair. DNA pol ι Antibodies are validated for multiple applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). DNA polymerase iota (DNA pol ι) is a specialized enzyme that plays a significant role in translesion synthesis, allowing cells to bypass DNA lesions during replication. This function is vital for maintaining genomic stability and preventing mutations that could lead to cancer. Understanding the activity and regulation of DNA pol ι is essential for elucidating mechanisms of DNA damage tolerance and repair pathways. DNA pol ι research has revealed important insights into cellular responses to DNA damage and potential therapeutic targets. Investigating DNA pol ι function has enhanced our understanding of cancer development and progression. Current research focuses on how DNA pol ι contributes to mutation prevention and DNA repair mechanisms. Santa Cruz Biotechnology monoclonal antibodies for DNA pol ι enable researchers worldwide to advance scientific understanding of DNA repair processes and cancer biology.

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DNA pol ι Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

DNA pol ι Antibody (NN7)

sc-101026mouse IgG3 κ616-716 (h)WB, IP, ELISAh
2
(3)

DNA pol ι CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

DNA pol ι CRISPR/Cas9 KO Plasmid (h)

sc-406351hGene KnockoutGFP0
(0)

DNA pol ι HDR Plasmid (h)

sc-406351-HDRhHomology Directed RepairPuromycin0
(0)

DNA pol ι Double Nickase Plasmid (h)

sc-406351-NIChGene KnockoutPuromycin0
(0)

DNA pol ι Double Nickase Plasmid (h2)

sc-406351-NIC-2hGene KnockoutPuromycin0
(0)

DNA Pol ι CRISPR/Cas9 KO Plasmid (m)

sc-424078mGene KnockoutGFP0
(0)

DNA Pol ι HDR Plasmid (m)

sc-424078-HDRmHomology Directed RepairPuromycin0
(0)

DNA Pol ι Double Nickase Plasmid (m)

sc-424078-NICmGene KnockoutPuromycin0
(0)

DNA Pol ι Double Nickase Plasmid (m2)

sc-424078-NIC-2mGene KnockoutPuromycin0
(0)

DNA pol ι CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

DNA pol ι CRISPR Activation Plasmid (h)

sc-406351-ACThGene ActivationPuro, Blast, Hygro0
(0)

DNA pol ι CRISPR Activation Plasmid (h2)

sc-406351-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

DNA pol ι Lentiviral Activation Particles (h)

sc-406351-LAChGene ActivationPuro, Blast, Hygro0
(0)

DNA pol ι Lentiviral Activation Particles (h2)

sc-406351-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

DNA Pol ι CRISPR Activation Plasmid (m)

sc-424078-ACTmGene ActivationPuro, Blast, Hygro0
(0)

DNA Pol ι CRISPR Activation Plasmid (m2)

sc-424078-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

DNA Pol ι Lentiviral Activation Particles (m)

sc-424078-LACmGene ActivationPuro, Blast, Hygro0
(0)

DNA Pol ι Lentiviral Activation Particles (m2)

sc-424078-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

DNA pol ι siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

DNA pol ι siRNA (h)

sc-37785hGene SilencingN/A0
(0)

DNA pol ι shRNA Plasmid (h)

sc-37785-SHhGene SilencingPuromycin0
(0)

DNA pol ι shRNA (h) Lentiviral Particles

sc-37785-VhGene SilencingPuromycin0
(0)

DNA pol ι siRNA (m)

sc-37786mGene SilencingN/A0
(0)

DNA pol ι shRNA Plasmid (m)

sc-37786-SHmGene SilencingPuromycin0
(0)

DNA pol ι shRNA (m) Lentiviral Particles

sc-37786-VmGene SilencingPuromycin0
(0)