DNA Ligase I Antibody (1A9): sc-47703

DNA Ligase I Antibody (1A9) is a mouse monoclonal IgG1 antibody that detects DNA Ligase I (LIGI) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). DNA Ligase I is crucial for maintaining genome integrity, as anti-DNA Ligase I antibody (1A9) recognizes a protein that plays a vital role in DNA replication and repair by catalyzing phosphodiester bond formation between adjacent 5′ phosphoryl and 3′ hydroxy termini at single breaks in duplex DNA molecules. DNA Ligase I monoclonal antibody (1A9) targets a protein essential for joining Okazaki fragments on the lagging strand during DNA replication, ensuring accurate and efficient genetic material replication. DNA Ligase I (1A9) antibody detects a protein involved in sealing nicks during excision repair, which is essential for correcting DNA damage that can lead to mutations and genomic instability. Elevated levels of DNA Ligase I have been observed in various human tumors compared to benign tissues, indicating potential roles as a biomarker for cancer progression and a target for therapeutic intervention. DNA Ligase I (1A9) monoclonal antibody identifies a protein whose altered activity is associated with Bloom′s syndrome, a chromosomal breakage disorder, highlighting its importance in maintaining genomic stability. Anti-DNA Ligase I antibody (1A9) serves as an invaluable tool for researchers studying DNA repair mechanisms and cancer biology.

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DNA Ligase I Antibody (1A9) References:

1. Organic anion transporter 3 (OAT3) and renal transport of the metal chelator 2,3-dimercapto-1-propanesulfonic acid (DMPS).  |  Rödiger, M., et al. 2010. Can J Physiol Pharmacol. 88: 141-6. PMID: 20237588
2. OAT3-mediated extrusion of the 99mTc-ECD metabolite in the mouse brain.  |  Kikuchi, T., et al. 2014. J Cereb Blood Flow Metab. 34: 585-8. PMID: 24496177
3. Identification of OAT1/OAT3 as Contributors to Cisplatin Toxicity.  |  Hu, S., et al. 2017. Clin Transl Sci. 10: 412-420. PMID: 28689374
4. Organic anion transporter OAT3 enhances the glucosuric effect of the SGLT2 inhibitor empagliflozin.  |  Fu, Y., et al. 2018. Am J Physiol Renal Physiol. 315: F386-F394. PMID: 29412698
5. Dihydrophenanthrenes from Juncus effusus as Inhibitors of OAT1 and OAT3.  |  Li, X., et al. 2019. J Nat Prod. 82: 832-839. PMID: 30892891
6. Identification of Structural Features for the Inhibition of OAT3-Mediated Uptake of Enalaprilat by Selected Drugs and Flavonoids.  |  Ni, Y., et al. 2020. Front Pharmacol. 11: 802. PMID: 32547398
7. Drug Metabolites Potently Inhibit Renal Organic Anion Transporters, OAT1 and OAT3.  |  Zou, L., et al. 2021. J Pharm Sci. 110: 347-353. PMID: 32910949
8. Oral Proteasomal Inhibitors Ixazomib, Oprozomib, and Delanzomib Upregulate the Function of Organic Anion Transporter 3 (OAT3): Implications in OAT3-Mediated Drug-Drug Interactions.  |  Fan, Y., et al. 2021. Pharmaceutics. 13: PMID: 33670955
9. Drug transporters OAT1 and OAT3 have specific effects on multiple organs and gut microbiome as revealed by contextualized metabolic network reconstructions.  |  Jamshidi, N. and Nigam, SK. 2022. Sci Rep. 12: 18308. PMID: 36316339
10. Utilization of Rosuvastatin and Endogenous Biomarkers in Evaluating the Impact of Ritlecitinib on BCRP, OATP1B1, and OAT3 Transporter Activity.  |  Huh, Y., et al. 2023. Pharm Res. 40: 2639-2651. PMID: 37561322

The preferred DNA Ligase I antibody is DNA Ligase I Antibody (C-5): sc-271678.