DMGDH Antibody (E-6): sc-393178

DMGDH Antibody (E-6) is a mouse monoclonal IgG2b kappa light chain antibody that detects DMGDH protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DMGDH (E-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. DMGDH protein, also known as dimethylglycine dehydrogenase, is an 866 amino acid mitochondrial enzyme that plays a crucial role in choline catabolism by catalyzing the conversion of dimethylglycine to sarcosine, a process vital for maintaining proper metabolic function. DMGDH exists as a monomer and belongs to the gcvT family, utilizing flavin adenine dinucleotide (FAD) and folate as essential cofactors for enzymatic activity. DMGDH is encoded by a gene located on human chromosome 5q14.1, and mutations in this gene can lead to DMGDH deficiency, a condition characterized by symptoms such as muscle fatigue, a distinctive fish-like odor, and elevated levels of N,N-dimethylglycine in urine. DMGDH′s ability to regulate dimethylglycine levels is important for preventing metabolic disturbances, making anti-DMGDH antibody (E-6) a valuable tool for researchers studying metabolic pathways and related disorders.

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DMGDH Antibody (E-6) References:

1. Defect in dimethylglycine dehydrogenase, a new inborn error of metabolism: NMR spectroscopy study.  |  Moolenaar, SH., et al. 1999. Clin Chem. 45: 459-64. PMID: 10102904
2. Structure and analysis of the human dimethylglycine dehydrogenase gene.  |  Binzak, BA., et al. 2000. Mol Genet Metab. 69: 181-7. PMID: 10767172
3. Cloning of dimethylglycine dehydrogenase and a new human inborn error of metabolism, dimethylglycine dehydrogenase deficiency.  |  Binzak, BA., et al. 2001. Am J Hum Genet. 68: 839-47. PMID: 11231903
4. Rat liver dimethylglycine dehydrogenase. Flavinylation of the enzyme in hepatocytes in primary culture and characterization of a cDNA clone.  |  Lang, H., et al. 1991. Eur J Biochem. 198: 793-9. PMID: 1710985
5. Molecular basis of dimethylglycine dehydrogenase deficiency associated with pathogenic variant H109R.  |  McAndrew, RP., et al. 2008. J Inherit Metab Dis. 31: 761-8. PMID: 18937046
6. Dimethylglycine Deficiency and the Development of Diabetes.  |  Magnusson, M., et al. 2015. Diabetes. 64: 3010-6. PMID: 25795213
7. Genetic polymorphisms that affect selenium status and response to selenium supplementation in United Kingdom pregnant women.  |  Mao, J., et al. 2016. Am J Clin Nutr. 103: 100-6. PMID: 26675765
8. Folate deficiency affects histone methylation.  |  Garcia, BA., et al. 2016. Med Hypotheses. 88: 63-7. PMID: 26880641
9. Potential diagnostic and prognostic marker dimethylglycine dehydrogenase (DMGDH) suppresses hepatocellular carcinoma metastasis in vitro and in vivo.  |  Liu, G., et al. 2016. Oncotarget. 7: 32607-16. PMID: 27119355
10. Nonalcoholic steatohepatitis is associated with a state of betaine-insufficiency.  |  Sookoian, S., et al. 2017. Liver Int. 37: 611-619. PMID: 27614103
11. [DMGDH gene-related dimethylglycine dehydrogenase deficiency in a case].  |  Wang, XL., et al. 2017. Zhonghua Er Ke Za Zhi. 55: 709-710. PMID: 28881522
12. Tissue specificity of rat mitochondrial dimethylglycine dehydrogenase expression.  |  Lang, H., et al. 1994. Biochem J. 299 (Pt 2): 393-8. PMID: 7513513

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-DMGDH Antibody (E-6) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-DMGDH Antibody (E-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

DMGDH Antibody (E-6) Specifications

Alternate Product Name: DMGDH

Product Clone Name: E-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 449-483

Epitope Target: DMGDH

Epitope Species: human

Product Reactivity/Detection: DMGDH

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine and bovine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for DMGDH Antibody (E-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin