DMGDH Inhibitors
DMGDH Inhibitors are chemicals that decrease the expression of DMGDH, a mitochondrial protein involved in the demethylation of N,N-dimethylglycine to sarcosine. These inhibitors can work either through direct interaction with the enzyme or indirectly by influencing pathways that are critical for the enzyme's activity. Malonic acid, for instance, acts as a competitive inhibitor, competing with the natural substrate for the active site. On the other hand, compounds like Sodium Azide disrupt mitochondrial functions, thereby affecting the site where DMGDH operates.
DIDS and EDTA represent another approach by altering the protein's structure or chelating essential metal ions, respectively. These compounds offer alternative pathways to inhibit DMGDH's activity. It's crucial to consider that the chemicals listed are capable of affecting DMGDH under different biochemical conditions, and their efficacy can be influenced by various factors such as concentration and pH. This provides a broad arsenal for modulating the activity of DMGDH for research purposes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium azide | 26628-22-8 | sc-208393 sc-208393B sc-208393C sc-208393D sc-208393A | 25 g 250 g 1 kg 2.5 kg 100 g | $43.00 $155.00 $393.00 $862.00 $90.00 | 8 | |
Sodium azide inhibits DMGDH by disrupting mitochondrial functions, where DMGDH is localized. | ||||||
L-Phenylalanine | 63-91-2 | sc-394058 sc-394058A sc-394058B | 100 g 500 g 1 kg | $114.00 $466.00 $693.00 | 1 | |
L-Phenylalanine can inhibit DMGDH by acting as a competitive inhibitor. | ||||||
Sodium oxamate | 565-73-1 | sc-215880 sc-215880B sc-215880C sc-215880D sc-215880A | 5 g 100 g 250 g 1 kg 25 g | $77.00 $469.00 $1106.00 $4111.00 $152.00 | 14 | |
Sodium oxamate inhibits DMGDH by mimicking the substrate and binding to the active site. | ||||||
Imidazole | 288-32-4 | sc-204776 sc-204776A sc-204776B sc-204776C | 25 g 100 g 1 kg 5 kg | $27.00 $56.00 $84.00 $343.00 | 2 | |
Imidazole can inhibit DMGDH by binding to essential metal ions. | ||||||
Iodoacetic acid | 64-69-7 | sc-215183 sc-215183A | 10 g 25 g | $57.00 $99.00 | ||
Iodoacetic acid inhibits DMGDH by modifying sulfhydryl groups in the enzyme. | ||||||
Hydroxylamine solution | 7803-49-8 | sc-250136 | 100 ml | $72.00 | ||
Hydroxylamine solution reacts with carbonyl groups in the active site, inhibiting DMGDH. | ||||||