Dmc1 Antibody (1D12/4): sc-53268
- Dmc1 Antibody (1D12/4) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against ull length Dmc1 of human origin
- recommended for detection of Dmc1 of mouse, rat and human origin by WB, IP and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Dmc1 Antibody (1D12/4) for WB applications. These reagents are now offered in bundles with Dmc1 Antibody (1D12/4) (see ordering information below).
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Dmc1 Antibody (1D12/4) is a mouse monoclonal IgG1 antibody that detects Dmc1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Dmc1 plays a crucial role in meiotic recombination, a process essential for accurate chromosome segregation during gamete formation. Dmc1 is primarily located in the nucleus, where anti-Dmc1 antibody (1D12/4) facilitates detection of DNA double-strand break repair through homologous pairing and strand exchange, ensuring genetic diversity and stability in offspring. Nuclear localization of Dmc1 is vital for proper meiotic processes, and dysfunction in Dmc1 activity can lead to chromosomal abnormalities and infertility. Dmc1 interacts with several proteins involved in recombination, including Rad51 and Rad52, which underscores Dmc1′s significance in maintaining genomic integrity. Dmc1 (1D12/4) antibody serves as an invaluable tool for researchers studying DNA repair and recombination mechanisms, providing insights into molecular underpinnings of genetic stability and implications in various biological contexts.
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Dmc1 Antibody (1D12/4) References:
- Recent advances in functional conservation and divergence of recombinase RAD51 and DMC1. | Guo, YX., et al. 2022. Yi Chuan. 44: 398-413. PMID: 35729697
- DMC1 attenuates RAD51-mediated recombination in Arabidopsis. | Da Ines, O., et al. 2022. PLoS Genet. 18: e1010322. PMID: 36007010
- The FLIP-FIGNL1 complex regulates the dissociation of RAD51/DMC1 in homologous recombination and replication fork restart. | Zhang, Q., et al. 2023. Nucleic Acids Res. 51: 8606-8622. PMID: 37439366
- SCFRMF mediates degradation of the meiosis-specific recombinase DMC1. | Xu, W., et al. 2023. Nat Commun. 14: 5044. PMID: 37598222
- FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in pre-meiotic DNA replication and meiotic recombination. | Ito, M., et al. 2023. Nat Commun. 14: 6857. PMID: 37891173
- Positive and negative regulators of RAD51/DMC1 in homologous recombination and DNA replication. | Ito, M., et al. 2024. DNA Repair (Amst). 134: 103613. PMID: 38142595
- DMC1 and RAD51 bind FxxA and FxPP motifs of BRCA2 via two separate interfaces. | Miron, S., et al. 2024. Nucleic Acids Res. 52: 7337-7353. PMID: 38828772
- FIGNL1-FIRRM is essential for meiotic recombination and prevents DNA damage-independent RAD51 and DMC1 loading. | Zainu, A., et al. 2024. Nat Commun. 15: 7015. PMID: 39147779
- Mei5-Sae3 stabilizes Dmc1 nucleating clusters for efficient Dmc1 assembly on RPA-coated single-stranded DNA. | Wei, CD., et al. 2024. Nucleic Acids Res. 52: 11768-11784. PMID: 39275989
- Hop2-Mnd1 functions as a DNA sequence fidelity switch in Dmc1-mediated DNA recombination. | Peng, JC., et al. 2024. Nat Commun. 15: 9266. PMID: 39463417
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dmc1 Antibody (1D12/4) | sc-53268 | 200 µg/ml | $322.00 | |||
Dmc1 Antibody (1D12/4): m-IgG Fc BP-HRP Bundle | sc-536922 | 200 µg Ab; 10 µg BP | $361.00 | |||
Dmc1 Antibody (1D12/4): m-IgGκ BP-HRP Bundle | sc-534097 | 200 µg Ab; 40 µg BP | $361.00 | |||
Dmc1 Antibody (1D12/4): m-IgG1 BP-HRP Bundle | sc-544902 | 200 µg Ab; 20 µg BP | $361.00 |