Date published: 2026-5-30

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Dmc1 Inhibitors

Dmc1 (Disrupted Meiotic cDNA 1) Inhibitors represent a class of chemical compounds that play a crucial role in the field of molecular biology and genetics. Dmc1 is a protein primarily found in eukaryotic organisms, including humans, and it is integral to the process of meiosis, which is a specialized form of cell division involved in the formation of gametes (sperm and egg cells). During meiosis, Dmc1 acts as a recombinase enzyme, facilitating genetic recombination and ensuring the proper segregation of chromosomes. Dmc1 promotes homologous recombination, a complex process that involves the exchange of genetic material between homologous chromosomes, resulting in genetic diversity among offspring. Dmc1 Inhibitors are designed to interfere with the activity of the Dmc1 protein, typically by binding to its active site or disrupting its function in some way. By inhibiting Dmc1, these compounds can be valuable tools for researchers studying meiosis, DNA repair mechanisms, and genetic recombination. They can be used in laboratory settings to gain insights into the molecular processes underlying meiosis and the role of Dmc1 in maintaining genomic stability. Moreover, Dmc1 Inhibitors have the potential to elucidate the molecular mechanisms involved in various genetic disorders and could be instrumental in understanding the basis of these conditions at the cellular level. These compounds are crucial for advancing our understanding of fundamental biological processes, enabling scientists to unlock the mysteries of genetic diversity and hereditary diseases.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

RAD51 Inhibitor B02

1290541-46-6sc-507533
10 mg
$95.00
(0)

B02 inhibits DMC1 by disrupting its DNA binding and strand-exchange activities, preventing homologous recombination in DNA repair.

Arsenic(III) oxide

1327-53-3sc-210837
sc-210837A
250 g
1 kg
$89.00
$228.00
(0)

Arsenic trioxide disrupts DMC1 function by interfering with the formation of DMC1-ssDNA complexes, hindering homologous recombination in cancer cells.

MIRA-1

72835-26-8sc-204087
sc-204087A
10 mg
50 mg
$118.00
$452.00
1
(1)

NSC 19630 inhibits DMC1-mediated homologous recombination by disrupting the DMC1-ssDNA filament formation, preventing DNA repair in cancer cells.

Triapine

200933-27-3sc-475303
10 mg
$300.00
(0)

Triapine inhibits DMC1 by disrupting ribonucleotide reductase activity, leading to nucleotide pool depletion and reduced DNA repair in cancer cells.

Cisplatin

15663-27-1sc-200896
sc-200896A
100 mg
500 mg
$138.00
$380.00
101
(4)

Cisplatin induces DNA damage and interferes with DMC1's role in DNA repair, contributing to the cytotoxic effects in cancer cells.

Olaparib

763113-22-0sc-302017
sc-302017A
sc-302017B
250 mg
500 mg
1 g
$210.00
$305.00
$495.00
10
(1)

Olaparib inhibits PARP1, which interacts with DMC1, thereby preventing efficient homologous recombination and promoting synthetic lethality in cancer cells.

NU 1025

90417-38-2sc-203166
5 mg
$131.00
9
(1)

NU1025 inhibits PARP1, which in turn affects DMC1-mediated DNA repair, making it a potential strategy for cancer therapy.

Talazoparib

1207456-01-6sc-507440
10 mg
$795.00
(0)

BMN 673 is a PARP inhibitor that disrupts DMC1-mediated DNA repair, promoting the accumulation of DNA damage and cell death in cancer cells.

4-[4-Fluoro-3-[(4-methoxypiperidin-1-yl)carbonyl]benzyl]phthalazin-1(2H)-one

1174043-16-3sc-497005
5 mg
$430.00
(0)

AZD2461 inhibits PARP1, impairing the interaction between PARP1 and DMC1 and sensitizing cancer cells to DNA damage, resulting in cell death.