DGUOK Antibody (G-11): sc-398101

DGUOK Antibody (G-11) is a mouse monoclonal IgG1 antibody that detects DGUOK in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DGUOK, or deoxyguanosine kinase, is a crucial 277 amino acid protein localized in the mitochondria, where DGUOK plays a vital role in cellular metabolism. DGUOK functions as a homodimer and is highly expressed in various tissues, including the liver, muscle, and brain. DGUOK catalyzes the conversion of deoxyguanosine to dGMP using ATP, which is essential for the phosphorylation of purine deoxyribonucleosides within the mitochondrial matrix. This enzymatic activity is not only critical for maintaining mitochondrial DNA integrity but also serves as an important antiviral and chemotherapeutic target. Deficiencies in the DGUOK gene can lead to hepatocerebral mitochondrial DNA depletion syndrome, a serious condition characterized by reduced mitochondrial DNA copy number, resulting in severe liver failure and neurological disorders. Anti-DGUOK antibody (G-11) is an invaluable tool for researchers studying mitochondrial function and related pathologies.

The preferred DGUOK antibody is DGUOK Antibody (H-3): sc-376267.