DGUOK Antibody (H-3): sc-376267
- DGUOK Antibody (H-3) is a mouse monoclonal IgG2a κ DGUOK antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 170-277 mapping at the C-terminus of DGUOK of mouse origin
- DGUOK Antibody (H-3) is recommended for detection of DGUOK of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-DGUOK Antibody (H-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for DGUOK Antibody (H-3) for WB applications. These reagents are now offered in bundles with DGUOK Antibody (H-3) (see ordering information below).
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DGUOK Antibody (H-3) is a mouse monoclonal IgG2a kappa light chain antibody that detects DGUOK protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-DGUOK antibody (H-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. DGUOK, also known as deoxyguanosine kinase, is a crucial 277 amino acid enzyme localized in the mitochondria, where DGUOK plays a vital role in the phosphorylation of purine deoxyribonucleosides. This process is essential for maintaining mitochondrial DNA integrity, as DGUOK catalyzes the conversion of deoxyguanosine to deoxyguanosine monophosphate using ATP. DGUOK function is particularly important in tissues with high energy demands, such as the liver, muscle, and brain, as DGUOK supports mitochondrial DNA replication and repair. DGUOK deficiencies can lead to severe consequences, including hepatocerebral mitochondrial DNA depletion syndrome, characterized by reduced mitochondrial DNA copy number, liver failure, and neurological abnormalities. DGUOK (H-3) antibody′s ability to effectively detect this critical protein makes DGUOK (H-3) antibody an invaluable tool for research into mitochondrial function and related disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
DGUOK Antibody (H-3) References:
- The deoxyguanosine kinase gene is mutated in individuals with depleted hepatocerebral mitochondrial DNA. | Mandel, H., et al. 2001. Nat Genet. 29: 337-41. PMID: 11687800
- Mitochondrial DNA depletion and dGK gene mutations. | Salviati, L., et al. 2002. Ann Neurol. 52: 311-7. PMID: 12205643
- A novel mutation in the deoxyguanosine kinase gene causing depletion of mitochondrial DNA. | Taanman, JW., et al. 2002. Ann Neurol. 52: 237-9. PMID: 12210798
- Mitochondrial DNA depletion can be prevented by dGMP and dAMP supplementation in a resting culture of deoxyguanosine kinase-deficient fibroblasts. | Taanman, JW., et al. 2003. Hum Mol Genet. 12: 1839-45. PMID: 12874104
- New DGK gene mutations in the hepatocerebral form of mitochondrial DNA depletion syndrome. | Mancuso, M., et al. 2005. Arch Neurol. 62: 745-7. PMID: 15883261
- Kinetic properties of mutant deoxyguanosine kinase in a case of reversible hepatic mtDNA depletion. | Mousson de Camaret, B., et al. 2007. Biochem J. 402: 377-85. PMID: 17073823
- Clinical and molecular features of mitochondrial DNA depletion due to mutations in deoxyguanosine kinase. | Dimmock, DP., et al. 2008. Hum Mutat. 29: 330-1. PMID: 18205204
- Cloning and expression of human deoxyguanosine kinase cDNA. | Johansson, M. and Karlsson, A. 1996. Proc Natl Acad Sci U S A. 93: 7258-62. PMID: 8692979
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DGUOK Antibody (H-3) | sc-376267 | 200 µg/ml | $322.00 | |||
DGUOK Antibody (H-3): m-IgGκ BP-HRP Bundle | sc-522902 | 200 µg Ab, 40 µg BP | $361.00 | |||
DGUOK Antibody (H-3): m-IgG2a BP-HRP Bundle | sc-546124 | 200 µg Ab; 10 µg BP | $361.00 | |||
DGUOK Antibody (H-3) AC | sc-376267 AC | 500 µg/ml, 25% agarose | $424.00 | |||
DGUOK Antibody (H-3) HRP | sc-376267 HRP | 200 µg/ml | $322.00 | |||
DGUOK Antibody (H-3) FITC | sc-376267 FITC | 200 µg/ml | $336.00 | |||
DGUOK Antibody (H-3) PE | sc-376267 PE | 200 µg/ml | $349.00 | |||
DGUOK Antibody (H-3) Alexa Fluor® 488 | sc-376267 AF488 | 200 µg/ml | $364.00 | |||
DGUOK Antibody (H-3) Alexa Fluor® 546 | sc-376267 AF546 | 200 µg/ml | $364.00 | |||
DGUOK Antibody (H-3) Alexa Fluor® 594 | sc-376267 AF594 | 200 µg/ml | $364.00 | |||
DGUOK Antibody (H-3) Alexa Fluor® 647 | sc-376267 AF647 | 200 µg/ml | $364.00 | |||
DGUOK Antibody (H-3) Alexa Fluor® 680 | sc-376267 AF680 | 200 µg/ml | $364.00 | |||
DGUOK Antibody (H-3) Alexa Fluor® 790 | sc-376267 AF790 | 200 µg/ml | $364.00 |