Desmin Antibody (B-7): sc-271677
- Desmin Antibody (B-7) is a mouse monoclonal IgG2a κ, cited in 10 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 413-445 near the C-terminus of Desmin of human origin
- recommended for detection of Desmin of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including canine
- See Desmin (RD301): sc-23879 for Desmin antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Desmin Antibody (B-7) for WB and IHC(P) applications. These reagents are now offered in bundles with Desmin Antibody (B-7) (see ordering information below).
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Desmin Antibody (B-7) is a mouse monoclonal IgG2a antibody that detects Desmin in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Desmin is a crucial intermediate filament protein that plays a significant role in maintaining the structural integrity and function of muscle cells. Desmin (B-7) antibody targets proteins located near the Z line in sarcomeres, where Desmin forms a network connecting adjacent myofibrils, facilitating the transmission of mechanical forces during muscle contraction. This structural organization is vital for muscle function, ensuring the contractile apparatus operates efficiently and synchronously. Desmin′s interactions with other proteins, such as dystrophin and various membrane-associated proteins, are essential for the stability and integrity of muscle fiber architecture. Mutations in the gene encoding Desmin can lead to severe muscle disorders, including adult-onset skeletal myopathy, highlighting Desmin′s importance in muscle health and disease. Anti-Desmin antibody (B-7) serves as an invaluable tool for researchers studying muscle biology and related pathologies, providing insights into Desmin′s role in both normal physiology and disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Desmin Antibody (B-7) References:
- Tragedy in a heartbeat: malfunctioning desmin causes skeletal and cardiac muscle disease. | Goldfarb, LG. and Dalakas, MC. 2009. J Clin Invest. 119: 1806-13. PMID: 19587455
- Ubiquitylation by Trim32 causes coupled loss of desmin, Z-bands, and thin filaments in muscle atrophy. | Cohen, S., et al. 2012. J Cell Biol. 198: 575-89. PMID: 22908310
- Desmin modifications associate with amyloid-like oligomers deposition in heart failure. | Agnetti, G., et al. 2014. Cardiovasc Res. 102: 24-34. PMID: 24413773
- Desmin Mutation in the C-Terminal Domain Impairs Traction Force Generation in Myoblasts. | Charrier, EE., et al. 2016. Biophys J. 110: 470-480. PMID: 26789769
- AAV9-mediated gene transfer of desmin ameliorates cardiomyopathy in desmin-deficient mice. | Heckmann, MB., et al. 2016. Gene Ther. 23: 673-9. PMID: 27101257
- Condensed desmin and actin cytoskeletal communication in lipid droplets. | Miyasaka, Y., et al. 2019. Cytoskeleton (Hoboken). 76: 477-490. PMID: 31626391
- Desmin prevents muscle wasting, exaggerated weakness and fragility, and fatigue in dystrophic mdx mouse. | Ferry, A., et al. 2020. J Physiol. 598: 3667-3689. PMID: 32515007
- Desmin and CD31 immunolabeling for detecting venous invasion of the pancreatobiliary tract cancers. | Shin, J., et al. 2020. PLoS One. 15: e0242571. PMID: 33253282
- The AAA-ATPase ATAD1 and its partners promote degradation of desmin intermediate filaments in muscle. | Aweida, D. and Cohen, S. 2022. EMBO Rep. 23: e55175. PMID: 36278411
- Differential expression of desmin in the uterine myometrium and cervix as a possible mechanism for successful parturition in rats. | Takamatu, M., et al. 2023. Reprod Biol. 23: 100726. PMID: 36603297
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Desmin Antibody (B-7) | sc-271677 | 200 µg/ml | $322.00 | |||
Desmin Antibody (B-7): m-IgG Fc BP-HRP Bundle | sc-537679 | 200 µg Ab; 10 µg BP | $361.00 | |||
Desmin Antibody (B-7): m-IgGκ BP-HRP Bundle | sc-535022 | 200 µg Ab; 40 µg BP | $361.00 | |||
Desmin Antibody (B-7): m-IgG2a BP-HRP Bundle | sc-548084 | 200 µg Ab; 10 µg BP | $361.00 | |||
Desmin (B-7) Neutralizing Peptide | sc-271677 P | 100 µg/0.5 ml | $69.00 |