Decorin Antibody (C-11): sc-518162
- Decorin Antibody (C-11) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 214-236 of Decorin of mouse origin
- recommended for detection of Decorin of mouse origin by WB, IP, IF and ELISA
- Anti-Decorin Antibody (C-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Decorin Antibody (C-11) for WB applications. These reagents are now offered in bundles with Decorin Antibody (C-11) (see ordering information below).
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Decorin Antibody (C-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects Decorin of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Decorin antibody (C-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Decorin is a small leucine-rich proteoglycan (SLRP) that plays a crucial role in the extracellular matrix by binding to collagen types I, II, and IV, thereby influencing the structural integrity and mechanical properties of tissues. Decorin′s unique structure, characterized by a core protein containing ten leucine-rich repeats and glycosaminoglycan chains, allows interaction with various growth factors and matrix molecules, such as fibronectin and thrombospondin. This interaction is vital for regulating cellular activities, including proliferation and differentiation, and for maintaining tissue homeostasis. Additionally, Decorin acts as a negative regulator of transforming growth factor beta (TGFβ), which is significant in modulating fibrotic responses and inflammation. Dysregulation of Decorin expression, particularly in inflammatory joint diseases, can lead to cartilage destruction, highlighting its importance in both normal physiology and disease states. The human Decorin gene is located on chromosome 12q21.33 and encodes a 359 amino acid protein, underscoring its evolutionary conservation and functional significance across species.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Decorin Antibody (C-11) References:
- Decorin has an appetite for endothelial cell autophagy. | Neill, T., et al. 2013. Autophagy. 9: 1626-8. PMID: 23989617
- Human Metaplastic Breast Carcinoma and Decorin. | Boström, P., et al. 2017. Cancer Microenviron. 10: 39-48. PMID: 28653173
- Decorin is a pivotal effector in the extracellular matrix and tumour microenvironment. | Zhang, W., et al. 2018. Oncotarget. 9: 5480-5491. PMID: 29435195
- Decorin deficiency promotes epithelial-mesenchymal transition and colon cancer metastasis. | Mao, L., et al. 2021. Matrix Biol. 95: 1-14. PMID: 33065248
- Regulation of decorin by ursolic acid protects against non-alcoholic steatohepatitis. | Zheng, Y., et al. 2021. Biomed Pharmacother. 143: 112166. PMID: 34560554
- The effect of topical decorin on temporal changes to corneal immune cells after epithelial abrasion. | Wu, M., et al. 2022. J Neuroinflammation. 19: 90. PMID: 35414012
- Decorin Inhibits Dermal Mesenchymal Cell Migration and Induces Scar Formation. | Takaya, K., et al. 2022. Plast Reconstr Surg Glob Open. 10: e4245. PMID: 35425688
- Decorin knockdown is beneficial for aged tendons in the presence of biglycan expression. | Beach, ZM., et al. 2022. Matrix Biol Plus. 15: 100114. PMID: 35818471
- Decorin in the spatial control of collagen mineralization. | Bai, Y., et al. 2024. Mater Horiz. 11: 3396-3407. PMID: 38690683
- Decorin attenuates hypertrophic scar fibrosis via TGFβ/Smad signalling. | Cui, J., et al. 2024. Exp Dermatol. 33: e15133. PMID: 39045898
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Decorin Antibody (C-11) | sc-518162 | 200 µg/ml | $322.00 | |||
Decorin Antibody (C-11): m-IgG Fc BP-HRP Bundle | sc-550675 | 200 µg Ab; 10 µg BP | $361.00 | |||
Decorin Antibody (C-11): m-IgGκ BP-HRP Bundle | sc-550669 | 200 µg Ab; 40 µg BP | $361.00 | |||
Decorin Antibody (C-11): m-IgG1 BP-HRP Bundle | sc-550674 | 200 µg Ab; 20 µg BP | $361.00 | |||
Decorin Antibody (C-11) AC | sc-518162 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Decorin Antibody (C-11) HRP | sc-518162 HRP | 200 µg/ml | $322.00 | |||
Decorin Antibody (C-11) FITC | sc-518162 FITC | 200 µg/ml | $336.00 | |||
Decorin Antibody (C-11) PE | sc-518162 PE | 200 µg/ml | $349.00 | |||
Decorin Antibody (C-11) Alexa Fluor® 488 | sc-518162 AF488 | 200 µg/ml | $364.00 | |||
Decorin Antibody (C-11) Alexa Fluor® 546 | sc-518162 AF546 | 200 µg/ml | $364.00 | |||
Decorin Antibody (C-11) Alexa Fluor® 594 | sc-518162 AF594 | 200 µg/ml | $364.00 | |||
Decorin Antibody (C-11) Alexa Fluor® 647 | sc-518162 AF647 | 200 µg/ml | $364.00 | |||
Decorin Antibody (C-11) Alexa Fluor® 680 | sc-518162 AF680 | 200 µg/ml | $364.00 | |||
Decorin Antibody (C-11) Alexa Fluor® 790 | sc-518162 AF790 | 200 µg/ml | $364.00 |